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Elevated Plus Maze
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- Anxiety testing system for rats & mice
- Four arms are arranged in the shape of a cross
- Two arms have side walls and an end wall ("closed arms") - the two other arms have no walls
("open arms").
- Closed arm walls can be individually inserted into guide rails
- The open arms are surrounded by small ledges to prevent the animal from falling from the maze
- The maze is fastened to a light-weight support frame.
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The Elevated Plus Maze test is one of the most widely used models to test anxiety in small rodents. It
is based upon their natural aversion to heights and open spaces which is decreased by anxiolytically
effective drugs.
We provide both fully computerized systems equipped with infrared location sensors and non-automated
systems for use in the TSE VideoMot2 system. Analysis parameters in both
system include among others open arm time and number of open arm visits. Total arm entries are used as
a measure of general activity.
Vogel Test System
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- Tests the ability of anxiolytic drugs to disinhibit behavior usually suppressed by punishment
- Can be configured for an unlimited number of measuring places
- Software-controlled lick/shock ratio, shock intensity & length, measuring mode, recording
interval, total duration
- Number of licks & shocks per time interval are automatically transferred into an Excel
worksheet
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The fully computerized Vogel Test System is used to monitor the effect of anxiolytic drugs in small
laboratory animals that are water-deprived. They are tested in special cages featuring a conductive
floor grid and a drinking bottle with stainless steel nipple connected to a shock generator. Monitoring
of animal licks is performed by very low electrical currents applied to the nipple that are below the
animal's perception level.
After a previously specified number of licks an electric shock is applied to the nipple - the animal
controls the shock frequency by withdrawing from the drinking tube. Anxiolytic drugs significantly
increase licking rate and therefore number of shocks applied.
Tail Suspension Monitor
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- Available as a single-channel basic configuration for a measuring station or as a computerized
measuring system for maximum convenience
- In the computerized system up to 16 channels are displayed in real-time
- Time of activity, immobility, and the amplitude in percent of total measuring range are
calculated for up to 16 channels simultaneously and are simultaneously stored in an Excel worksheet
in user-defined intervals for further statistical calculations
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The TSE Tail Suspension Monitor is a device for screening antidepressants in mice, rats or other small
laboratory animals that are subjected to an aversive situation. The aversive situation is induced by
suspending the animal by the tail for a short period of time. An animal in that situation alternates
between two kinds of behavior: agitation (mobility) and immobility. The cumulative immobility time is a
measure of the animal's degree of helplessness ("depression"). Treatment with antidepressant drugs
reduces immobility time.
Learned Helplessness
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- Well-known rat model of depression
- Test box with electrified floor and wall, cue light set, response lever, house light and
loudspeaker
- Various shock characteristics can be set including adjustable pulse frequency and shock
application pattern
- The special box design ensures that the animal is not able to escape the shock
- Ready-to-use conditioning and test protocols
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Learned Helplessness is a well-known animal model of depression. Exposure of rats to an unpredictable,
inescapable moderate foot shock will induce response deficits in a subsequent shock escape test. This
"helpless" behavior may improve during treatment with antidepressant drugs.
Our fully automated test box is controlled using the multi-purpose Operant Behavior software. We provide
predefined paradigms for conditioning and test. Results include number of escape reactions, number of
reactions in the rest phase plus total shock duration received in each trial. Alternatively the
free-programming option is available for generating custom test procedures.
Copyright © 1995 - 2008 TSE Systems International Group - All rights reserved.
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