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Multi Conditioning System
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- One system - eight paradigms and more!
- High-resolution IR technology
- Sound & light stimuli – electric shocks & air puffs
- Variable compartment design – tactile and / or visual discrimination
- Versatile designing of experiments
- Fully automated simultaneous operation in multiple chambers
- Software features in compliance with GLP requirements
- Simultaneous video monitoring
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The TSE Multi Conditioning System (MCS) combines conditioning, depression and anxiety paradigms within one single
unique modular hardware and software platform. The MCS - designed as a combination system for mice & rats –
allows classical Active/Passive/Step-Down Avoidance experiments, Learned Helplessness, Place Preference as well
as Fear Conditioning testing. In addition, unconditioned anxiety can be tested with the Light-Dark paradigm or
Locomotor Activity with the activity module. Moreover, while this is already cost-effective and flexible, the
combination of different paradigms allows the design of completely novel experiments far ahead of present
approaches. The combination is more than the sum of its single components!
TSE Multi Conditioning System - One system - eight paradigms and more!
Fear Conditioning System Advanced
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- Evaluate fear learning, retention and extinction in rodents
- High-resolution infrared sensors in 3 dimensions for ultra-precise movement detection with up to 100Hz
sampling rate
- Free definition of experimental designs for trace & delay fear conditioning
- "New Context" – adjustment of visual, auditory and tactile cues
- Can be converted into a Light-Dark or Place Preference System
- Integrated ultra-sound loudspeakers for evaluation of panic responses in rats – unique in the market
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The TSE Fear Conditioning System Advanced is a widely used and proven multi-purpose system for studying contextual
and cued fear in mice and rats. In classical fear conditioning, a behavioral paradigm based on associative
emotional learning, the subject is given a cue, usually an auditory signal, followed by an electric shock.
Alternatively only an electric shock can be given. In the subsequent retention trial the animal is tested for
its fear of both the context and/or the auditory cue.
The TSE Fear Conditioning System Advanced allows the free definition and storage of experimental designs.
The user-defined sequence of stimuli (including light and noise stimuli) is applied in up to 8 measuring stations
that are controlled by a single PC. The comprehensive graphical and numerical evaluation of the animal's fear
response over the course of the experiment includes calculation of freezing frequency and duration as well as a
variety of other essential evaluation parameters such as activity, hypoactivity & hyperactivity times, number
of rearing events, average speed or % area explored by the animal.
With optional dedicated compartments the system can also be used to run unconditioned anxiety tests (Light-Dark
test) and Place Preference experiments. A system upgrade is available for extensive Open Field analysis.
Active Avoidance
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- Fully computerized bidirectional avoidance conditioning system ("Step-Through Avoidance" or "Shuttle-Box")
- Software-controlled light, shock, tactile (air puff) and auditory stimuli (10 kHz fixed or adjustable
2?20 kHz)
- Optional application of WAV files for acoustic discrimination
- Flexible program editor for generation of user-defined procedures
- Optional extension for Learned Helplessness testing
- Optional Passive Avoidance conversion set
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The TSE Active Avoidance system allows simultaneous operation of up to 4 test boxes. We provide rat-only, mouse-only
and combination systems for both species. A gate, an automatic door or a hurdle with optional electrical stimulus
can be used as compartment divider. Monitoring of animal movement and location is performed with a uni-dimensional
infrared sensor strip with species-specific sensor distances. In the combination system for rats and mice
species-specific test cages can be easily interchanged.
The user-friendly Windows software is designed to run a variety of test protocols. Adjustable time parameters
include habituation, time to shock, shock length, maximum run duration and inter-stimulus interval. Data analysis
provides a results table listing conditioned, unconditioned and inter-stimulus transfers and mean reaction times.
Distance traveled is presented as a measure of activity throughout the trial. Measured values of several animals
can be summarized for group analysis.
The Active Avoidance system is integrated into the modular Active/Passive Avoidance & Learned Helplessness
combination system as a space-saving economic alternative to individual specialized testing systems.
Learned Helplessness tests can be performed by combining the Active Avoidance paradigm
with a preceding inescapable shock session. For Passive Avoidance experiments black exchange
walls and an automatic door are available – a dedicated software module is provided in the software package
for this paradigm.
The paradigm is also an integral part of our new Multi Conditioning System.
Passive Avoidance Basic
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- Simultaneous operation of up to 4 test boxes
- Rat-only, mouse-only and combination systems
- Software-controlled light and shock
- Optional sound-attenuating housing
- Optional Active Avoidance conversion set
- Can also be used for Light-Dark tests
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The TSE Passive Avoidance system Basic is a learning & memory testing system designed for the classical "step-through" paradigm –
a task based on associative emotional learning. A lit and a dark compartment are separated by a motorized door. The floor grid delivers
an electric shock when the animal enters the dark side. Monitoring of animal movement is performed with uni-dimensional infrared
sensors with species-specific distances (rats or mice).
The user-friendly Windows software allows to run flexible pre-exposure, training and retention protocols. Data analysis provides the
response latency, the number of transfers and time of stay in both compart?ments.
The Passive Avoidance system Basic is integrated into the modular Active/Passive Avoidance & Learned Helplessness combination
system as a space-saving economic alternative to individual specialized testing systems. The paradigm is also an integral part of our
new Multi Conditioning System that allows a more detailed evaluation of animal movement due to its 3-dimensional
sensor configuration.
Passive Avoidance Advanced
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- Simultaneous operation of up to 2 test boxes
- Extra-large compartments for increased exploration & activity behavior
- Light-intensity up to 1200 Lux – high level of aversiveness
- High-resolution movement data for evaluation of baseline activity
- Rearing data as a measure of exploration
- Jumping data for evaluation of the animal's shock reaction
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The TSE Passive Avoidance System Advanced is a newly developed system that has been optimized for Passive Avoidance experiments.
It is designed as a combination system for both rats & mice. A lit and a dark compartment are divided by a motorized door. The
floor grid delivers an electric shock when the animal enters the dark side. In contrast to the Passive
Avoidance Basic system it features a three-dimensional infrared sensor frame that registers movement in 3 dimensions. In
combination with extra-large compartments a detailed analysis of the animals exploratory behavior and activity is made
possible.
Run flexible pre-exposure, training and retention protocols. Data analysis outputs response latency, number of transfers and
time of stay in both compartments as well as tables and graphs for detailed analysis of exploration inside the 2 compartments
incl. inactivity time, speed, rearing and jumping events.
TSE also provides a fully-computerized 3-dimensional Passive Avoidance Advanced setup as an integral part of our new
Multi Conditioning System.
Pole Jump Avoidance
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- One-way active avoidance task for mice and rats
- Central pole with structured surface that provides a grip for the animal
- Microswitch sensors register the animal's presence on the pole
- Automated software-controlled generation of conditioned stimuli (sound, light) and unconditioned
stimuli (foot shock)
- Multi-purpose programming software for user-defined test protocols
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The Pole Jump avoidance task is a one-way active avoidance conditioning task. TSE Systems provides fully automated
test boxes for mice and rats that are equipped with shockable grid floor, stimulus light and loudspeaker for sine
sound & noise generation. The acrylic front door allows the operator to observe the animal throughout the
experiment. The animal has to climb up a pole in response to a stimulus – usually a sound – to avoid a shock
delivered through the floor of the box.
Control of the pole jump experiment is done with the flexible TSE Operant Behavior software; this allows the
definition of user-defined experimental designs with the integrated free programming editor. Results such as the
reaction time are stored in ASCII files for further statistical evaluation.
Place Preference System
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- Assess the rewarding properties of a psychotropic drug
- Fully automated three-compartment test boxes for mice or rats
- Select from a variety of wall specifications and floor inserts to facilitate discrimination between
compartments
- Compartment dividers: Closed dividers, tunnel gates, or manual or software-controlled doors
- High-resolution infrared sensors monitor entries into compartments and locomotor activity
- Up to 8 boxes can be operated simultaneously with one PC
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Conditioned place preference (CPP) is a widely used technique to assess the rewarding properties of a psychotropic
drug. Treatment with a specific preparation is repeatedly paired with a distinct environment while a control
treatment is paired with a different environment. When the animal has access to both environments, preference
for the drug-paired cues will indicate the rewarding effects of the test drug.
TSE Place Preference test boxes are available in a variety of configurations with easily exchangeable wall
elements, integrated lamps used to counterbalance preferences for specific compartments, and differently
structured floor inserts to facilitate tactile discrimination. The system comes complete with easy-to-use Windows
software. Data acquisition is started automatically when the first light-beam sensor is interrupted after the
animal has been placed in the box. Data analysis in the test trial includes number of visits, time spent and
distance traveled in each compartment.
Operant Behavior Systems
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- Versatile modular Skinner boxes for rats & mice
- Standard, weight-adjustable, illuminated or retractable levers or nose-poke response modules
- Cue lamps in one-lamp and triple-lamp configurations
- Choice of food and liquid reinforcers
- Intravenous self-administration configuration
- Self-stimulation with intracranial electrodes & stimulus generator
- Standard schedules include FR, VR, PR, FI, VI, PI, DRH and DRL, Geller conflict, drug discrimination
- Integrated flexible program editor for user-defined protocols
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TSE Operant Behavior Systems are fully computerized Skinner boxes custom-built from a wide choice of individual
components. A variety of different function modules is available which are easily mounted on the base construction
with one or two walls. Each Skinner box is a completely self-contained unit in a sound and light-attenuating
fan-ventilated housing suitable for all standard operant tasks.
Box control and data acquisition are made easy with the comprehensive TSE Operant Behavior software package. Run
one of the preprogrammed schedules which are continuously being further developed according to the latest research
applications. Alternatively individually designed schedules can be created employing our unique and easy-to-learn
free programming language.
We also provide dust-free precision pellets for mice and rats.
Special box configurations allow Learned Helplessness experiments to be performed.
The new TSE PhenoMaster System (Link zu PhenoMaster) designed as an automated modular behavioral and physiological
phenotyping platform allows the performance of operant behavior studies in a home cage environment under stress-free
conditions.
5-Hole-Box System
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- "5-Choice Serial Reaction Time" task – attention testing system for mice or rats
- Food or liquid reinforcement with variable reinforcer position
- Present bursts of white noise as distractor (selective attention)
- Optional sine sound (2?20kHz) in up to two individual loudspeakers mounted at selected holes
- Optional TTL trigger signal with user-defined timing
- Integrated flexible program editor for user-defined protocols
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The TSE 5-Hole-Box system is designed to perform attention tests based on visual discrimination ("5-choice
serial reaction time task"). Basically the 5-hole-box is an operant chamber without levers. Short-lasting visual
stimuli are given in pseudo-random order in all of 5 stimulus holes mounted on a curved wall or in selected
holes only. Responses into the holes are monitored with infrared sensors - correct responses are reinforced.
Reward can be given directly into the response holes or in one common reward area on the opposite wall. In
order to increase attention, load distracting sound or noise can be presented through a loudspeaker module.
The loudspeaker is mounted on a flexible arm that can be swiveled into any position above or beside the box.
The TSE Operant Behavior software package includes ready-to-use standard paradigms. The software generates a
table of results that discriminates incorrect and correct responses, outputs average latencies for both correct
and incorrect responses and calculates the number of premature responses as a measure of motor impulsivity. A
frequency distribution lists number of visits in each hole. For maximum flexibility the integrated program editor
allows the generation of user-defined paradigms such as the 2-Choice Reaction Time task (2-CRT) or other
procedures.
The box can be operated in a sound-attenuating housing that can be equipped with a low-light sensitive camera.
We also provide dust-free precision pellets for mice and rats.
Dustless Precision Pellets
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Our nutritionally balanced dustless precision pellets are
suited for all applications where highly precise feeding is required.
- The pellets are nutrionally balanced and virtually dust-free.
- Hassle-free performance in automatic feeders.
- Suitable as a maintenance diet as well as a behavioral reward.
- Available in sizes of 14/ 20/ 45 mg.
- Tested routinely for hardness, weight and height.
- Produced in a GMP environment assuring accurate and consistent diet composition.
Certification
The nutritional content on every lot of diet is analyzed by an independent laboratory prior to
shipment. The results of analysis are available upon request.
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Nutritional Assays
Nutritional assays and chemical screens are provided to ensure product consistency.
Ingredients
Protein, fat, fiber, ash and moisture
Purified Formula
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Caloric Value
3.62 cal/mg
Ingredients
Casein, sucrose, fiber, dextrose, Dl-methionine, L-cystine, choline bitartrate, corn oil, corn syrup,
mineral mix, vitamin mix, flowing and flavoring agents
Shelf Life
12 months in cool, dry storage
Ordering Information
| Cat-No. | Description |
| 259901-PEL-14/50T |
Precision-Pellets 14 mg, dustless
BioServ Purified Formula
For TSE Pellet Dispenser (14 mg) and other pellet dispensers.
Pack = 50.000 pellets. |
| 259901-PEL-20/50T |
Precision-Pellets 20 mg, dustless
BioServ Purified Formula
For TSE Pellet Dispenser (20 mg) and other pellet dispensers.
Pack = 50.000 pellets. |
| 259901-PEL-45/50T |
Precision-Pellets 45 mg, dustless
BioServ Purified Formula
For TSE Pellet Dispenser (45 mg) and other pellet dispensers.
Pack = 50.000 pellets |
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