Learned Helplessness I+II

Learned Helplessness (LHN) is a well-known behavioral paradigm to study depression-like behavior and anti-depressant drugs in animals. Unpredictable, inescapable foot shock exposure of animals induces response deficits in a subsequent escape learning task.
TSE Systems offers three different approaches to studying LHN.

In the system based on an Operant Behavior (Skinner box) apparatus the animal can escape the shock during the test session by pressing a lever.

The fully automated LHN test is controlled by the multi-purpose Operant Behavior software that provides predefined paradigms for pre-exposure and test. A free-programming language is available for generating custom procedures.

The alternative approach to study LHN in mice & rats is based on the Active Avoidance task, which is also part of the new Multi Conditioning System.

• Helplessness test based on operant response (lever pressing) or active avoidance
• Operant test box for rats or mice with electrified floor and wall, cue light set, response lever, house light and loudspeaker
• Various shock characteristics including adjustable pulse frequency and shock application pattern
• Special box design ensures that the animal cannot escape the shock
• Ready-to-use programmed conditioning and test protocols
• Analysis of Depression