PhenoMaster NG

Advanced Multipurpose Platform for Rodent Metabolic, Behavioral & Physiological Studies

Selection of Cages
PhenoMaster

Next-Generation Rodent Metabolic Phenotyping.

PhenoMaster NG is more than a phenotyping platform — it’s a trusted scientific solution designed for researchers who demand precision, adaptability, and full data transparency. Engineered for advanced metabolic, behavioral, and physiological studies in rodents. It enables comprehensive insights across key domains of modern research.

The system integrates indirect calorimetry, ingestive behavior and liquid intake, activity, exercise and cognitive monitoring, and detailed microbiome gas analysis (CH₄, H₂), stable isotope tracing (¹³CO₂) — all within a modular home-cage environment.

PhenoMaster NG adapts to your experimental needs with plug-and-play architecture, optimized cage components, and seamless compatibility with telemetry and optogenetic tools. Whether you’re investigating obesity, metabolic dysfunction, neurobehavioral phenotypes, or gut–brain axis interactions, PhenoMaster NG delivers consistent and reproducible data you can trust – tailored to the complexity of your research.

No black box. No chemicals. No post-hoc corrections. Just traceable, peer-reviewed data — validated in over 2,000 scientific publications worldwide.

Built to evolve with the demands of research, PhenoMaster NG offers unmatched performance and scientific clarity in metabolic and behavioral exploration.

 

 

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6 Reasons to Choose PhenoMaster NG

The most complete modular system on the market:  Only PhenoMaster NG offers the widest range of integrated modules – delivering the full picture of metabolism, behavior, cognition, and physiology in one platform.

30% more cage space = better data: Unique cage design promotes locomotor activity and more naturalistic behavior.

Scalable from 4 to 64 cages: Ideal for both pilot studies and large cohorts – no compromise in performance.

Exclusive research modules: Only PhenoMaster includes Weight Lifting, Resistance Running, Cognitive Testing & Hydrogen Monitoring.

No extrapolation, full accuracy:
High-resolution O₂/CO₂ sensors with T90-compliant readings — no curve-fitting, no shortcuts. Choose true data, not assumptions.

Smart design = faster workflow: PhenoMaster’s intelligent system and cage architecture ensures quick calibration (just 20 min), easy handling, and fast cleaning – saving your time at every step.

The Widest Range of Phenotyping Tools in One System

Indirect Calorimetry

Drinking Feeding Body Weight

Microbiome Activity

Stable Isotope Tracing

Activity

Learning and Memory

Climate Chamber

Exercise

Add-ons

Smart by Design. Proven in Research.

30% more space. Less stress. More reliable data.

Weight Sensors
High-precision sensors, capturing micro events: feeding, drinking and body weight. With onboard 32-bit digitization, linearization, for precise measurement at the highest sampling rate.
Cage Lid
Made of transparent components for light influx optimization and better preservation of circadian rhythms. All modules are fixed to the lid for an optimal airflow through the cage.
Body Weight
Red tubular housing invites animals to rest and measures accurately the body weight of visiting animals. Acts as a cage enrichment and improves animal welfare.
Infrared Activity Frame
XYZ frame with 5mm physical resolution (1.25mm spatial resolution) for finest locomotor activity analysis at 100Hz sampling rate.
Running Wheel
For activity and exercise monitoring. Available in different configurations: for voluntary, workload and motor skill running, including enable/disable function.
Supportive Frame
for fast cage cleaning and easy handling during experiments.
Individual Cage Controller
It is the smart brain of every cage and powers all sensors. Sensors use a modern architecture that allows them to be removed and added without interfering with other sensors’ data collection ability.
Climate Board for 24/7 animal welfare monitoring
Continuously measures the temperature, ambient pressure, and humidity in the home cage. Can additionally be used to quantify water balance.
Access Control
An automated door restricts access to food and/or water based on time, amount, or average consumption of individuals and/or control group.
Food Container
with SpillProtect technology. Available in different configurations for a broad variety of food types.
The Latest and Most Advanced Innovation in Indirect Calorimetry for Rodents.

CaloMax HS – the Latest Innovation in Indirect Calorimetry for Rodents.

At the core of PhenoMaster lies CaloMax HS — our most advanced platform for indirect calorimetry in rodents. Designed for unmatched speed, accuracy, and flexibility, CaloMax HS enables real-time measurement of oxygen (O₂) and carbon dioxide (CO₂), along with methane (CH₄), hydrogen (H₂), and stable isotopes (¹³CO₂) for advanced microbiome and oxidative metabolism studies.

With intelligent diagnostics, automated humidity control, and scalable architecture from 4 to 24 cages, CaloMax HS delivers the best-in-class balance between data quality and sampling speed, even under complex environmental conditions.

Available as both single-channel and multi-channel configurations to support the throughput your research demands.

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Explore Our Full Selection of Cages for Rodent Phenotyping

Equipped with HEPA filter for sterile conditions. Available in pull or push ventilation configurations

IsoCage for Germ-Free Studies

Equipped with HEPA filter for sterile conditions. Available in pull or push ventilation configurations.

High-resolution basal metabolic

Speakman BMR Chamber

Hood-style cage co-developed with Prof. John R. Speakman, offering hugh-resolution basal metabolic rate measurement with simultaneous behavior monitoring, 1 sec time resolution for exceptional accuracy.

Opto Mouse Cage

Designed for optogenetic and fiber-based experiments. Supports counter-balance arm and is ideal for gut-brain studies.

Metabolic PhenoCage

Enables separate collection of urine and feces for microbiome and metabolic studies. Includes high-speed cooling for sample preservation.

Group-Housing Cage with RFID

Supports social housing and individual animal tracking via RFID antennas. Enables longitudinal studies of behavior and metabolism in socially housed animals.

Rat Cage Type 3

Classic rat metabolic cage can be configured with various modules and is perfect for use in climate cabinets.

Rat Cage Type 4

Spacious metabolic cage for obese rats or larger rodents. Suitable for use in climate-controlled cabinets.

PhenoMaster NG, phenotyping platform, precision research, metabolic studies, behavioral studies, physiological studies, rodents, indirect calorimetry, ingestive behavior, liquid intake, activity monitoring, exercise monitoring, cognitive monitoring, microbiome gas analysis, CH₄, H₂, stable isotope tracing, ¹³CO₂, modular home-cage, plug-and-play, telemetry, optogenetics, obesity research, metabolic dysfunction, neurobehavioral phenotypes, gut–brain axis, reproducible data, validated publications, scientific clarity.

Mouse Cage Type 2

Classic metabolic cage for mouse is available in different configurations tailored to specific research applications.

New Cutting-Edge Data Analysis Package. Powerful. Flexible. User-Friendly.

TSE Analytics streamlines multi-dataset management, facilitating collaboration and ensuring reproducibility – all in one user-friendly package. Effortless automatic metadata extraction and dataset processing provides you full control over your analysis by enabling you to filter or group the data by animal/experiment and defining custom time bins for a more narrow-down analysis. Advanced analytics and visualization capabilities include versatile tools, histograms, correlation calculations, robust ANOVA/ANCOVA options, and dimensionality reduction.
TSE Analytics unlocks the full potential of your research by simplifying complex data analysis.

Mean Energy Expenditure of animals grouped by the temperature factor.

Correlation of energy expenditure and activity.

Boxplot of individual RER data.

Mean Energy Expenditure of animals grouped by the temperature factor.

Correlation of energy expenditure and activity.

Boxplot of individual RER data.

PhenoMaster – Synchronized Metabolic Phenotyping.

PhenoMaster delivers high-definition, real-time data across all connected modules — from indirect calorimetry to intake, activity, and body weight. All signals are fully synchronized for each individual cage, ensuring precise temporal alignment and system-wide data integrity.

Modular components interact based on user-defined logic, so events in one module can trigger responses or annotations in others — enabling dynamic, customized experimental designs.
All data is visualized instantly and stored for detailed analysis, ensuring transparency, reproducibility, and scientific confidence.

Researchers worldwide rely on PhenoMaster to generate peer-reviewed, publication-ready data across metabolism, behavior, and physiology.

The only system that thinks across modules — just like your experiment does.

 

 

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Support Package to Ensure Your Research Success

Lab Environmental Monitor for Real-time Tracking of Crucial Experiment-Influencing Parameters

Smooth Integration of Third-Party Devices Software and Hardware

Premium Warranty and Service Package, incl. immediate remote assistance

Application-focused Scientific Training and 24/7 Support

Preventive Maintenance Packages and Regular Software Updates

Annual User Workshops and Collaboration Opportunities

“The TSE PhenoMaster system has been critical to advancing our science, and our ability to precisely quantify a broad range of metabolic outcomes in our rodent models. The service team has aided us every step of the way in troubleshooting and keeping us up and running. Working with Gary has been amazing. He assisted us every step of the way from evaluating a purchase to ensuring prompt and attentive service even after the purchase.”

Brian DeBosch
Associate Professor | Washington University School of Medicine

“For over a decade, we have relied on the TSE Phenomaster equipment to evaluate feeding behavior and in vivo use of energy substrates through indirect calorimetry and locomotor activity analysis. The integration of the different technical features into home cages to carry out a variety of measurements immediately caught our attention, as this solution greatly facilitates the adaptation of the mice to their environment.”

Dr. Daniela Cota
Team Leader / Team Energy balance and obesity | University of Bordeaux

“We love to work with our 24 PhenoMaster home cages for focused mouse nutritional and physiological studies! Highly accurate and extendible. We already implemented fermentation gas sensors for gut microbial activity and isotopic sensors for metabolic fluxes and still continue to add more parameters.”

Dr. Evert van Schothorst
Associate Professor | Human and Animal Physiology, Wageningen University

Compatible with

Stellar Telemetry

Multichannel implantable telemetry for In-vivo monitoring of physiological parameters.

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NeuroLux

Wireless battery-free optogenetics system for freely moving animals in any setup.

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Animal Gate, behavioral research, mice, rats, automated access control, programmable software, RFID identification, compartment management, movement control, air-puff training, behavioral conditioning, real-time weight measurement, health monitoring, personalized protocols, access restriction, black and white lists, tubes, tunnels, stairways, experimental setups.

PhenoWorld

Unique and customized automated phenotyping solution for mice or rats.

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IntelliCage, automated behavioral assessment, home cage monitoring, mice, rats, social interaction, enriched environment, cognitive performance, animal welfare, minimal handling, high reproducibility, standardized setup, animal gate, controlled access, RFID identification, programmable protocols, running wheels, metabolic cages, stress reduction, research workflow.

IntelliCage

Fully automated system for group-housed rodent behavioral and cognitive phenotyping allowing to preserve social environment.

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Key Publications

Efthymiou, V., Ding, L., Balaz, M., Sun, W., Balazova, L., Straub, L. G., Dong, H., Simon, E., Ghosh, A., Perdikari, A., Keller, S., Ghoshdastider, U., Horvath, C., Moser, C., Hamilton, B., Neubauer, H., & Wolfrum, C. (2023). Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice. Nature Communications, 14(1), Article 1.

González-García, I., García-Clavé, E., Cebrian-Serrano, A., Le Thuc, O., Contreras, R. E., Xu, Y., Gruber, T., Schriever, S. C., Legutko, B., Lintelmann, J., Adamski, J., Wurst, W., Müller, T. D., Woods, S. C., Pfluger, P. T., Tschöp, M. H., Fisette, A., & García-Cáceres, C. (2023). Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1. Cell Metabolism, 35(3), 438-455.e7.

Park, E.-J., Kim, H.-S., Lee, D.-H., Kim, S.-M., Yoon, J.-S., Lee, J.-M., Im, S. J., Lee, H., Lee, M.-W., & Lee, C.-W. (2023). Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nature Communications, 14(1), Article 1.

Petersen, J., Englmaier, L., Artemov, A. V., Poverennaya, I., Mahmoud, R., Bouderlique, T., Tesarova, M., Deviatiiarov, R., Szilvásy-Szabó, A., Akkuratov, E. E., Pajuelo Reguera, D., Zeberg, H., Kaucka, M., Kastriti, M. E., Krivanek, J., Radaszkiewicz, T., Gömöryová, K., Knauth, S., Potesil, D., … Adameyko, I. (2023). A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Nature Communications, 14(1), Article 1.

Verlande, A., Chun, S. K., Song, W. A., Oettler, D., Knot, H. J., & Masri, S. (2022). Exogenous detection of 13C-glucose metabolism in tumor and diet-induced obesity models. Frontiers in Physiology, 13.

PhenoMaster History

We built first system for monitoring breathing parameters.
First fully automated system for monitoring food, drink and XYZ activity in rats.
We developed first indirect calorimetry system CaloSys for mice.
Together with Prof. M.Tschöp we developed our first LabMaster with CaloSys, Drink/Food and XYZ.
Integration of new automated modules: body weight, running wheel, operant wall.
Further development of rat system. Start EU project RatStream.
Further development of mouse system within Start EU project PhenoScale.
Implementation of an alarm module for real-time vital parameter alerts.
First continuous indirect calorimetry system with 1 sec time resolution. New brand name – PhenoMaster.
PhenoMaster was placed in a custom-built Isolator for germ-free mice.
We pioneered the use of CH₄ & H₂ gas sensors for in-vivo detection at mice.
We pioneered the use of Isotope Sensors in combination with indirect calorimetry in rodents.
Introducing PhenoMaster Next Generation with new design and configuration.
New group-housing cage system for mice.
New development – Weightlifting module for resistance exercise test.
New High-Speed sensors for indirect calorimetry.
New TSE Analytics package.

PhenoMaster Locations

115
USA
5
Canada
10
Austria
1
Belgium
4
Czech Republic
60
Germany
7
Denmark
1
Estonia
4
Finland
24
France
13
Great Britain
3
Hungary
1
Ireland
5
Israel
4
Italy
2
Latvia
7
Poland
5
Russia
17
Spain
6
Sweden
15
Switzerland
5
The Netherlands
1
Turkey
61
China
2
India
1
Saudi Arabia
4
Singapore
12
South Korea
4
Taiwan
4
Australia

Center of Knowledge

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PhenoMaster Blog Posts

The Rhythm of Life: Prof. Paul Petrus on How Our Body’s Clock Shapes Metabolism and Health

Join us for an exclusive interview with Prof. Paul Petrus from the Petrus Lab. His research focuses on endocrinology and diabetes, with a particular interest…

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The Expanding Impact of PhenoMaster: Fueling Scientific Discovery

PhenoMaster. A story of Scientific Trust.

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A Visionary in Neuroscience: Dr. Diego Bohórquez on brain-gut axis

A Visionary in Neuroscience: Dr. Diego Bohórquez on Healing the Brain Through the Gut

A Visionary in Neuroscience: Dr. Diego Bohórquez on Healing the Brain Through the Gut

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The power of mice genetics: advancing life science research and tackling society's biggest health challenges.

Mice are incredibly similar to humans, sharing around 97.5% of their working DNA. That’s why genetically engineered mice have become an essential tool for investigating…

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Unlocking the Secrets of Gut Microbiota and Host Energy Metabolism: A Novel Approach with PhenoMaster-based Isolator System

The gut microbiota plays a vital role in regulating the host’s energy metabolism. Until recently, studies have shown that mice without microbiota accumulate less fat…

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