The most accurate and reliable respirometry system measures the animal’s Oxygen consumption and Carbon Dioxide production to calculate key metabolic parameters, including the Respiratory Exchange Ratio and Energy Expenditure.
CaloMax HS is our latest innovation — a complete re-engineering of rodent indirect calorimetry from the inside out. Built on a flexible modular architecture, it integrates all critical components into a compact, intelligent system designed for long-term stability, precision, and effortless operation.
At its core lies a newly developed Multi-Sensor Board that unites all gas analyzers — O₂, CO₂, ¹³C, CH₄, and H₂ — within a single coordinated unit. This short-path configuration minimizes signal delay and ensures fast, synchronized response across all parameters. Combined with intelligent gas-flow control and optimized chamber integration, CaloMax HS delivers highly accurate metabolic data with minimal noise and exceptional reproducibility.
An embedded Intelligent Diagnostic System continuously monitors hardware and sensor performance, communicating with the control software in real time to predict maintenance needs and prevent downtime. Together with Ethernet-based communication, simplified cable management, and a robust air-conditioning and pumping system, CaloMax HS defines a new generation of smart, durable, and efficient calorimetry solutions for metabolic research.
Flexible Architecture: Scalable design supporting 4–24 cages, optimized for precision, throughput, and long-term adaptability.
Multi-Sensor Board: Integrated O₂, CO₂, ¹³C, CH₄, and H₂ detection in one synchronized unit for fast and consistent gas analysis.
Air-Conditioned Unit: Intelligent humidity control ensuring stable performance across all sensor types.
SureFlow Pump with Backup: Continuous airflow and automatic fail-safe operation for uninterrupted measurements.
Intelligent Diagnostic System: Real-time monitoring of all hardware components to prevent downtime and maintain calibration accuracy.
Efficient Compact Design: Streamlined, Ethernet-based communication and reduced cabling for a cleaner setup and easier handling.
CaloSys Professional is a fully automated, high-throughput indirect calorimetry system offering unmatched flexibility. Whether you require continuous real-time monitoring or prefer multiplexed measurements at set intervals, CaloSys adapts to your research needs with both PUSH and PULL modes.
Our system boasts a variety of gas sensors, making it suitable for a wide range of research applications in rodent metabolism. Plus, the upgradable architecture ensures access to cutting-edge technology.
Unparalleled Accuracy, Transparent Results: Focus on your groundbreaking discoveries with confidence, knowing CaloSys delivers raw, unprocessed data. Our cutting-edge sensor technology boasts exceptional speed and accuracy, eliminating the need for further manipulation.
Conduct your research with confidence, knowing your results are based on reliable data.
User-adjustable Air Flow 0,3-5 l/m
PULL and PUSH calorimetry (for conventional or hypoxia studies)
Continuous, Multiplexed sampling or Accelerated Multiplexed sampling
Variety of High-Speed sensors with longest possible life span
Clean physical elimination of humidity (instead of chemical or calculations)
Fastest automated sensors calibration
Phenomaster offers several versions of gas sensor configurations that differ in time resolution and measurement speed. The advantage lies in the diverse modes and the seamless transition between them. CaloSys Professional’s unique scalability allows users to upgrade from Classic Multiplex to Accelerated Multiplex and Continuous Calorimetry. This flexibility is paramount as research goals shift over time, ensuring your system evolves with scientific inquiries.
Directly Available and Accessible Raw Sensor Data
Environmental Monitoring Module
Alarm Module
Extension with H2, CH4, C13 gas sensors
Programmable Mass Flow Controllers
Temperature and Humidity Measurement
Witness the power of comprehensive metabolic data in a single window! This graph showcases the impact of fasting, refeeding, and temperature on mice in real time. Observe the evident decrease in Respiratory Exchange Ratio (RER) during fasting, followed by the rise upon refeeding. This level of detailed insight is achieved through our high-resolution (1-second) indirect calorimetry system, capturing every data point throughout the experiment.
PhenoMaster software empowers researchers to achieve breakthrough results in metabolic research. Our intuitive interface guides users in optimizing cage settings, ensuring the accuracy and consistency of your data. PhenoMaster connects existing modules like activity, exercise, and ingestive behavior trackers, allowing you to establish robust correlations between various physiological parameters.
This unmatched level of adaptability extends beyond the cage. CaloSys Pro integrates with special gas sensors, allowing you to share them seamlessly across diverse research settings – from standard home cages to metabolic wheels or treadmills. This flexibility empowers researchers to conduct multifaceted metabolic studies tailored to specific needs.
Seamlessly Analyze All Aspects of Metabolism in One Unified Platform.
TSE Systems offers the most complete and future-ready portfolio in rodent indirect calorimetry — combining three system architectures designed to match different research needs. The CaloSys Professional platform delivers robust and high-precision O₂/CO₂ measurements in both Accelerated Multiplex Mode (for high-throughput data acquisition across multiple cages) and Continuous Real-Time Mode (for uninterrupted precision studies).
The latest CaloMax HS represents a complete re-engineering of TSE’s calorimetry technology. It integrates a Multi-Sensor Board for simultaneous multi-gas detection (O₂, CO₂, ¹³C, CH₄, H₂), an Air-Conditioned Unit for humidity removal and stabilization, and an Intelligent Diagnostic System ensuring continuous system communication and reliability.
All configurations — from CaloSys to CaloMax — can operate in either Pull or Push airflow modes, allowing researchers to tailor the system to their specific experimental paradigm, whether standard metabolic phenotyping, microbiome analysis, or hypoxia studies. This unique combination of architectural flexibility, sensor precision, and animal-centric airflow design makes TSE Systems the leading choice for high-fidelity metabolic research.
Standard configuration measures O₂ and CO₂ for RER and energy expenditure (EE). Optional sensors extend functionality to: • ¹³C Stable Isotope Tracing — for in vivo metabolic flux studies; • CH₄ and H₂ detection — for microbiome activity and fermentation research.
All analyzers are combined in one Multi-Sensor Board with short gas paths, ensuring rapid response, synchronized readings, and minimal maintenance.
The Flexible Architecture of CaloMax HS allows configurations from 4 to 24 cages. • Single-Channel mode delivers ultra-precise data for smaller studies or long-term monitoring. • Multi-Channel mode increases throughput without sacrificing stability.
High airflow does not shorten measurement time or improve precision; it simply pushes more air through the cage, which can dilute gas concentrations and cool the animal, leading to compensatory thermogenesis and artificially elevated energy expenditure (EE).
Both TSE calorimetry systems allow user-adjustable airflow between 0.5 and 5 L/min, giving full flexibility to adapt flow settings to your study design. Researchers can set the highest possible airflow — however, we do not recommend it.
Rather than relying on excessive airflow, which can dilute gas signals and stress animals, CaloMax HS is designed around true sampling precision. We focus on what matters scientifically — sampling rate, synchronization, and physiological stability without physiological artifacts.
Each sensor type performs best under specific humidity and temperature conditions. The Air-Conditioned Unit pre-conditions air before it reaches the sensors, automatically adjusting humidity and temperature according to the number and type of active detectors. This prevents drift, extends sensor lifespan, and ensures reproducible data even during long-term studies.
The Intelligent Diagnostic System continuously monitors sensor status, gas flow, and internal hardware performance. All data is transmitted to the control software in real time. When deviations occur, the system generates a clear diagnostic report, allowing Remote Diagnostics from TSE’s technical team to minimize downtime and optimize performance without interrupting ongoing measurements.
• Pull-Mode (default for PhenoMaster NG): draws air from the cage toward the analyzer, ensuring steady sampling and minimal disturbance — ideal for use inside climate chambers.
• Push-Mode: delivers a defined air composition into the cage, creating slightly positive pressure — suitable for hypoxia/hyperoxia or germ-free applications. Both modes are available, providing full flexibility for various research paradigms.
Yes. When integrated with TSE climate chambers, multiple groups can run simultaneously — for instance, one at room temperature and another at thermoneutrality. All environmental parameters (temperature, humidity, light) are synchronized with the experiment timeline, ensuring maximum efficiency and true comparative analysis while supporting 3R principles.
Both. CaloMax HS functions as a stand-alone calorimetry unit (to be connected to the metabolic treadmill or stand-alone metabolic wheel) or as a fully integrated module within the PhenoMaster NG ecosystem, combining metabolic, behavioral, and physiological monitoring in one synchronized setup.
CaloMax HS supports mice and rats through interchangeable cage types and airflow settings. Switching species requires only changing the metabolic cages and adjusting settings in the software — a process completed in minutes thanks to Smart Cage Architecture.
Yes. ¹³C Stable Isotope Tracing allows direct monitoring of substrate utilization and metabolic fluxes, while CH₄ and H₂ detection provides valuable insight into microbial fermentation. The Air-Conditioned Unit and Multi-Sensor Board ensure stable conditions and synchronized multi-gas measurements for these advanced applications.
We provide expert support and high-performance equipment for efficient, reliable preclinical research. Contact us – Your success matters.