Microbiome Activity Monitoring

Pioneered by TSE, our Advanced Gas Sensors detect H₂ (hydrogen), CH₄ (methane), and H₂S (hydrogen sulfide) in rodents for Gnotobiotic Research, including Germ-free Animals.

Gain Comprehensive Insights on Microbiome Dynamics

PhenoMaster leads in sensor innovation, enabling real-time monitoring of microbiome activity in lab animals and elevating research precision. This advancement is vital for scientists investigating germ-free animals in metabolic, microbiome, and aging studies. Paired with critical modules like food intake monitoring and control, feces collection, and indirect calorimetry, researchers gain profound insights into the impact of diet or treatments on microbiome dynamics.

H2 evolution reflects adaptation to dietary carbohydrates

Mice fed with a low digestible diet produced more hydrogen than their counterparts, while at ad libitum consumption of a high digestible diet, hydrogen levels were left unchanged.

Microbiome activity monitoring

Ensuring Safety for Gnotobiotic and Germ-Free Rodent Research

Gnotobiotic and germ-free animals require specialized housing to maintain their unique microbiological status and protect both the animals and the laboratory environment. Our customized PhenoMaster Isolators and Iso-Cages address this need perfectly.

By adding any of these special enclosures, you can confidently conduct research with gnotobiotic mice while keeping both your animals and the lab environment safe.

Microbiome activity monitoring

Metabolic Cage for Urine and Fecal Sample Collection

This dedicated metabolic cage is designed for precise urine and fecal separation, ensuring high-quality sample recovery for metabolic and microbiome studies.
Featuring a hydrophobic surface, it minimizes evaporation and contamination, guaranteeing reliable collection even during short-term experiments.

An integrated resting plate provides animals with a dry, comfortable area, reducing stress and allowing longer housing durations without compromising data integrity.
Optional food and water intake sensors, respirometry gas sensors can be added to correlate metabolic output with intake and behavior, providing a complete experimental profile.

Built with precision and animal welfare in mind, this cage enables reproducible, high-fidelity data essential for advanced metabolic and gut-brain axis research.

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Publications

Fernández-Calleja, J. M. S., Bouwman, L. M. S., Swarts, H. J. M., Billecke, N., Oosting, A., Keijer, J., & van Schothorst, E. M. (2019).. Nutrients, 11(9), Article 9

Hoces, D., Lan, J., Sun, W., Geiser, T., Stäubli, M. L., Barazzone, E. C., Arnoldini, M., Challa, T. D., Klug, M., Kellenberger, A., Nowok, S., Faccin, E., Macpherson, A. J., Stecher, B., Sunagawa, S., Zenobi, R., Hardt, W.-D., Wolfrum, C., & Slack, E. (2022).. PLOS Biology, 20(9), e3001743

Fernández-Calleja, J. M. S., Konstanti, P., Swarts, H. J. M., Bouwman, L. M. S., Garcia-Campayo, V., Billecke, N., Oosting, A., Smidt, H., Keijer, J., & van Schothorst, E. M. (2018).. Scientific Reports, 8(1), Article 1.