PreciseInhale® is an advanced laboratory system that lets scientists measure how inhaled particles act in our lungs and affect our health. Today’s standard technologies for this are largely unchanged since the 1950’s, often producing variable, unreliable data. Despite the lung’s impressive ability to get drugs into the body faster and more efficiently than other therapies, developing new inhaled medicines has been held back by poor data that fails to correlate early lab results and later clinical results—a failure that can cost pharma scientists millions in lost investment.

PreciseInhale® changes all that. It delivers results with a proven high correlation between laboratory and human testing—paving the way for more cost-efficient medicines for rapidly-rising global killers like asthma and COPD (chronic obstructive pulmonary disease)—and a new generation of inhaled drugs in broader therapeutic areas, like migraine, impotence, diabetes and influenza. PreciseInhale® is built in modules. It can be tailored closely to the customer’s specific needs. It has been purchased by both pharma scientists developing new treatments, and environmental researchers testing the effects of airborne particle pollutants.

Key features

  • Separating aerosol generation and dispensing. Aerosols are generated with a high-power air jet of 10-160 bar pressure. The energy is then siphoned off, leaving a plume of aerosol that is ‘pulled’ into a fine stream by a vacuum pump, enabling it to be dispensed separately across a range of exposure modules.

  • PreciseInhale®’s software monitors and measures aerosol in real time. Automated software and a light-scattering device maps and measures the aerosol concentration and breathing pattern in real time. This enables researchers to customize their aerosol to their exact needs, and generates detailed voluminous PK data, including particle size distribution data and Tmax and Cmax curves.

Inhaler Aerosol Generator

The inhaler actuation device is coupled to the PreciseInhale® in order to produce respirable aerosols and precisely dose each exposure object from any inhaler. Suitable for DPIs as well as pMDIs.


  • Precise repeatable dosing of exposure object
  • Allows coupling of any inhaler to the PreciseInhale®
  • (DPIs and MDIs/pMDIs)
  • Automatic actuation
  • Adjustable inhalation flow rate
  • Registration of pressure drop (DPIs)
  • USP (United States Pharmacopoeia) design

Exposure modules: 

  • XposeALI ®3D cell exposure module combines aerosol capability with 3D cell models cultured in an Air Liquid Interface (ALI). It enables studies of cellular effects induced by airborne particles.
  • DissolvIt ® enables in vitro simulation of absorption and dissolution of respirable particles in the lung epithelium.
  • This nose-only module exposes single rodents, one-at-a-time, to respirable aerosols from PreciseInhale® safely, gently and precisely - reducing standard deviation, the number of test animals needed and obtaining highly reliable pharmacokinetic data.
  • With the module for intratracheal inhalation exposures of rodents to respirable aerosols by the PreciseInhale® system, it is possible following administration to obtain pharmacokinetic data resembling clinical inhalation exposures.
  • Inhalation Sciences' isolated perfused and ventilated lung (IPL) system is a specially tailored version of the IPL designed for exposures of respirable aerosols from the PreciseInhale® system.