Latent Inhibition

 

  • Software controlled stimulus sine sound /noise generator for constant or pulsating sounds of variable frequency (2 – 22 kHz) and intensity (max 100dB)
  • Background white noise generator (max 100dB)

 

The latent inhibition paradigm is a task commonly used to examine attentional dysfunction in rodent models of certain psychiatric disorders, such as schizophrenia. It is based on the phenomenon that a familiar stimulus takes longer to acquire meaning as a conditioned stimulus (e.g. in predicting a shock) than an unfamiliar stimulus. Acquisition of an active avoidance response by an animal to a conditioned stimulus takes longer (is inhibited) if the stimulus was previously applied in a pre-exposure trial compared to an animal that has not been pre-exposed.

The Latent Inhibition module of the Multi Conditioning System belongs to the family of “2-compartment paradigms”, operated with a universal software package granting maximal user-friendliness and offering unsurpassed flexibility.