Open Field Arena
Activity & Exploration
The Open Field test is a widely used paradigm to study spontaneous locomotion, exploration and anxiety. Rodents show a natural tendency to avoid open and brightly lit spaces so they will usually stay close to the wall of the arena (thigmotaxis) – center avoidance is a measure of anxiety. Evaluate the animal´s baseline behavior or the change of this behavior in response to drug treatment, mutation, lesion or environment (illumination).
TSE provides Open Field arenas for rats and mice in several sizes, shapes (square-shaped, round) and colors (black, gray, white). Several Open Field cages can be combined to increase throughput. Place the arenas on special support frames or tables for comfortable handling. Typically used in combination with a video-tracking system such as the TSE VideoMot2 system an Open Field is selected to provide maximum contrast between animal and background. IR translucent Open Field arenas allow tracking of animals of any color under any light conditions – even in complete darkness – when they are combined with the TSE IR-Boxes.
TSE also provides dark inserts for the Open Field cages in 33% and 50% size to perform light-dark anxiety tests. In combination with TSE Rearing Frames, an accessory for the TSE VideoMot2 system, it is also possible to measure rearing movement, converting the Open Field into a true 3D detection system.
Forero A, Ku HP, Malpartida AB, Wäldchen S, Alhama-Riba J, Kulka C, Aboagye B, Norton WHJ, Young AMJ, Ding YQ, Blum R, Sauer M, Rivero O, Lesch KP. Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology 2020; 168: 108018
Mett A, Karbat I, Tsoory M, Fine S, Iwanir S, Reuveny E. Reduced activity of GIRK1-containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory. J Physiol. 2020 Oct 30. Epub ahead of print
Perdiguer L, Hnida M, Oberländer V, Xu X, Ahlbeck J, Bitzenhofer SH, Mulert C, Hanganu-Opatz IL. Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment. Neuron 2020; 105(1): 60-74