IntelliCage

The Ultimate Platform for Advanced Rodent Cognitive Phenotyping

IntelliCage - New Standard for Rodents Behavioral & Cognitive Phenotyping

Automated Group Housing with Individual Monitoring

Behavioral data often tell us less about cognition – and more about stress.

IntelliCage changes that. It is a fully automated system that allows group-housed mice to perform cognitive and social tasks without human interference.

Using RFID technology one IntelliCage can accommodate and track up to 16 mice or 8 rats while preserving natural social interaction. Its enriched and standardized environment minimizes handling, reduces stress, and delivers highly reproducible data with minimal workload.

To expand experimental control, an intelligent animal gate enables automated conditional access between the IntelliCage and external devices, streamlining workflows without disturbing the animals.

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Benefits Compared to Classical Behavioral Systems

IntelliCage provides a unified and automated platform for assessing a wide range of rodent behaviors like spontaneous activity, circadian rhythm, spatial preference, corner exploration, and complex patrolling patterns, all within a single standardized home-cage environment. By eliminating manual handling and human scoring, IntelliCage delivers higher data consistency and reproducibility across laboratories than traditional open-field or water-maze–based methods, while measuring the same core behavioral traits.

Your Benefits:
• Broad behavioral coverage in one system: activity, exploration, learning, and spatial preference
• Higher reproducibility through automated, standardized measurements
• Reduced variability by minimizing human handling and environmental disruption
• Continuous long-term monitoring for richer behavioral profiles
• Direct comparability to traits measured in classic tests (e.g., exploration, locomotion)
• Greater efficiency by focusing researcher time on interpretation rather than manual scoring

Locomotor and Exploratory Activity

The IntelliCage excels in exploratory behavior and locomotor activity assessments compared to traditional tests. Classic methods show data variability, leading to complex strain-by-laboratory interactions. IntelliCage providis automated and standardized measurements, ensuring higher data reproducibility accross sdifferent labs.

Spatial Learning

The system effectively measures spatial learning through paradigms similar to the Morris water maze test, but with significant time-saving benefits. Our research demonstrates a remarkable decrease in workload – up to 40 times faster than traditional methods – allowing researchers to conduct more experiments and expedite discoveries.

Social Behavior

IntelliCage facilitates the exploration of social interactions between rodents. By capturing parameters like spatial preferences and corner visitation patterns, researchers can gain valuable insights into social dynamics and communication within rodent groups.

Locomotor and Exploratory Activity

Modified from Lipp et al., 2005

Spatial Learning

Social Behavior

Why Scientist Switch to IntelliCage?

Naturalistic social housing within a standardized home-cage environment

Fully automated behavioral and cognitive assessment with individual identification

Minimal human intervention, reducing stress and improving task validity

High reproducibility and efficiency through continuous, unbiased data collection

Improved animal welfare through reduced handling and low-stress procedures

Extendable via programmable access control for complex studies

What Makes IntelliCage Unique?

Study Natural Behavior in Social Groups
House up to 16 mice or 8 rats together and collect individual behavioral data without isolation. This enables ecologically valid research and reduces stress-induced variability, thus leading to cleaner, more interpretable results.

Capture Rich Behavioral Data 24/7
Continuous monitoring across light and dark phases provides a complete picture of circadian rhythms, learning trajectories, and spontaneous behavior. This data cannot be captured with short, human-run tests.

Run Established Behavioral Paradigms Automatically
Validated tasks such as spatial learning, reversal learning, fixed ratio, and DRL can be implemented without manual handling. This increases standardization, reduces experimenter bias, and ensures protocol fidelity across studies and sites.

Reduce Labor and Resource Burden
Because animals remain in their home cage and tests run automatically, staff time, handling, and associated variability are dramatically minimized. Multiple paradigms can run in parallel without increasing workload.

Scale Up for High Throughput Screening
Operate up to four IntelliCages on one computer, enabling simultaneous testing of 64 mice or 32 rats. Ideal for phenotyping pipelines, consortium studies, or drug screening where large cohorts are essential.

Tailor Experiments to Your Scientific Question
Flexible, module-based programming allows you to design simple to highly complex behavioral protocols. Researchers can adapt tasks to genotype-specific needs, developmental stages, or intervention studies without hardware changes.

Diverse Behavioral Paradigms

Enables unbiased assessment of natural activity, circadian rhythms, and exploration without human interference, providing high ecological validity.

Reveals how animals navigate space and structure their daily routines, offering sensitive measures of hippocampal function and cognitive flexibility.

Allows detection of learning strategies and memory retention by quantifying how reliably animals choose or avoid specific locations.

Measures cognitive flexibility and adaptability—key readouts for prefrontal cortex function and disease models involving executive deficits.

Captures complex, self-organized behavioral routines that provide insight into habit formation and procedural memory.

Determines how effectively animals detect, interpret, and act upon environmental cues, enabling fine-grained analysis of sensory and cognitive processing.

Allows automated quantification of reward sensitivity using flavored or sweetened solutions, supporting research in affective disorders.

Reveals dominance structures and social strategies in group-housed animals, enabling ethologically meaningful assessments impossible in single-animal tests.

Provides precise control over reward and punishment schedules to measure motivation, decision-making, and instrumental learning.

Evaluates sustained effort, motivation, and motor planning under standardized operant conditions.

Tests impulse control and timing accuracy, supporting studies on attention, inhibition, and executive function.

Quantifies learning of aversive contingencies, allowing non-invasive assessment of anxiety-related and avoidance behavior.

Tracks how animals process, store, and update information over time, enabling long-term cognitive profiling in disease and intervention studies.

The Dark Tunnel Box (DTB) is an innovative environmental enrichment module designed for automated behavioral phenotyping in rodents.

Dark Tunnel Box – Natural Shelter for Better IntelliCage Data

The Dark Tunnel Box (DTB) adds a protected, burrow-like refuge directly underneath the IntelliCage, allowing rodents to express natural hiding and resting behavior. This reduces stress, stabilizes baselines, and enhances the clarity of cognitive and behavioral readouts in long-term automated studies.

Why It Improves Your Science?

Lower stress variance → clearer learning and memory signals
More naturalistic behavior → improved translational validity
Higher reproducibility → consistent results across cohorts and labs
Better task engagement → stronger effects in reward-based paradigms

Seamless IntelliCage Integration:

TraffiCage with 8 RFID antennas for precise tracking
Standardized burrow compartments for enriched housing
Central control unit synchronized with IntelliCage software
Plug-and-play compatibility with existing automated workflows

Why Scientists Choose the Dark Tunnel Box?

Naturalistic Enrichment
Provides a dark, burrow-like refuge that supports species-typical behaviors, creating a more ecologically relevant IntelliCage environment.

Stress and Anxiety Reduction
Allows animals to self-regulate and recover in a protected space, reducing anxiety-driven variability that can mask cognitive or treatment effects.

Improved Animal Welfare
Maintains essential hiding and resting opportunities that align with good husbandry practice and support long-term well-being during continuous testing.

Superior Data Quality and Reproducibility
Stabilizes behavioral baselines and minimizes stress-related noise, yielding clearer phenotypes and more consistent results across cohorts and laboratories.

Enhanced Mechanistic Insight for Neurobiology
Reduces confounding stress activation of neural circuits, enabling more accurate interpretation of learning, motivation, anxiety, and affective processes.

Seamless Integration and Workflow Efficiency
Works as a plug-and-play extension of IntelliCage, synchronizing automatically with existing RFID tracking and behavioral modules to enrich studies without adding workload.

More Natural Behavior. More Reliable Data.

The Dark Tunnel Box (DTB) enriches IntelliCage studies with a secure, light-free refuge that supports natural hiding and resting behavior. This reduces stress, accelerates adaptation, and produces cleaner, more interpretable behavioral signals.

By lowering anxiety-driven variability, the DTB helps establish stable baselines and improves reproducibility across long-term 24/7 automated testing, even in complete darkness. Researchers gain deeper insight into learning, anxiety modulation, and social interaction within a group-housed, fully automated environment.

Integrated TraffiCage technology with eight RFID antennas delivers precise spatial and activity tracking, seamlessly synchronized with IntelliCage behavioral metrics. This enables advanced correlations between environmental use and cognitive or emotional outcomes, enhancing both data quality and animal welfare.

Together, IntelliCage and the Dark Tunnel Box create an ecologically valid, low-stress platform for sophisticated behavioral phenotyping and continuous, hands-off monitoring in preclinical research.

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IntelliCage Software – Powering Smarter, Faster Behavioral Research

The IntelliCage software suite transforms complex behavioral studies into streamlined, fully automated workflows. Designed for researchers who demand precision and efficiency, its three powerful modules – Designer, Controller, and Analyzer – work together to deliver effortless experiment setup, flawless execution, and deep, high-resolution insights into rodent behavior. Whether you are running simple preference tests or multi-phase cognitive protocols, IntelliCage software gives you the control, clarity, and confidence to accelerate discovery in a social, real-world experimental environment.

Flexible Cluster Configuration
Detailed Behavioral Event Mapping
Intuitive Graphical User Interface
Fully Modular Design for Any Paradigm
Automated Day/Night Patterns and Scheduling

Define the complete hardware configuration for your IntelliCage setup.
Create detailed animal profiles including ID, transponder, sex, group, and cluster assignment.
Design single-phase or multi-phase experiments tailored to your cognitive, behavioral, or pharmacological research goals.

Designer lets you build complex behavioral paradigms with confidence and efficiency – no coding required.

Records all key events (e.g. visits, nosepokes and licks) and environmental parameters in real time.
Provides instant visualization of sensor and actor activity as the study unfolds.
Displays per-animal performance graphs for ongoing behavioral assessment.
Issues alerts when animals deviate from expected behavior (e.g., no visits or licks).

Controller ensures flawless automated execution, continuous oversight, and complete experimental traceability.

Filter data using Boolean logic to isolate specific conditions or time windows.
Compare filtered results while retaining access to the original dataset.
Save reusable filter presets to standardize analysis across experiments.
Export images and data files for publications and statistical software.

Analyzer gives you the power to transform dense behavioral streams into meaningful, reproducible scientific insights.

Publications

Kahnau, P., Jaap, A., Diederich, K., Gygax, L., Rudeck, J., & Lewejohann, L. (2023). Determining the value of preferred goods based on consumer demand in a home-cage based test for mice. Behavior Research Methods, 55(2), 751–766.

Kiryk, A., Janusz, A., Zglinicki, B., Turkes, E., Knapska, E., Konopka, W., Lipp, H.-P., & Kaczmarek, L. (2020). IntelliCage as a tool for measuring mouse behavior – 20 years perspective. Behavioural Brain Research, 388, 112620.

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“The Intellicage system is a great ethological platform providing high-throughput standardized quantification of the home-cage behavior of group-housed mice during circadian cycle. This allows good data comparability and reproducibility, and there is a high flexibility in the protocols to analyze both spontaneous and conditioned responses. In this socially-enriched and ethically-compliant environment, complex behaviors are recorded without major bias due to experimenter intervention and without stress compared to standard tests in which mice stand alone.”

Dr. Cyrille Vaillend
PI (DR1) | NeuroPSI Institute, Paris Saclay University

“…our laboratory has 6 IntelliCages along with add-ons (2 social boxes). I have more than 5 years of experience with this system and can provide only positive feedback regarding IntelliCage. Both hardware and software are reliable, in addition support by TSE is excellent. The system offers a great flexibility in design of various experiments…”

Dr. Vootele Voikar
University of Helsinki

“Following or avoiding other mice in corner visits” … “this is the first method that permits the mapping of the social networks of mice and the effects of those social networks on reward-induced behaviors”

Parkitna et al
PloS One 2014

“We are excited to be using the Intellicage system from TSE to further our understanding of legacies of stress. Being able to perform experiments with minimal experimenter-associated interference has elevated our portfolio of behavioral neuroscience approaches.”

Prof. Brian G. Dias, PhD
Professor of Pediatrics | University of Southern California

“IntelliCage plays a pivotal role in our translational research on Autistic spectrum disorder. We can assess 11 clinically relevant traits in mice within 2 months and screened 8 ASD models so far. This revealed shared (e.g., dominance) and model-specific (e.g., restrictive movement patterns) traits across models, foundational in ongoing drug development, highlighting the immense role IntelliCage plays preceding clinical trials.”

Seico Benner
Senior Researcher | NIES/Hamamatsu University School of Medicine, Japan

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PhenoMaster NG

Metabolic cage system for mouse, rat or larger animals. Suitable for calorimetry, behavioral and physiological studies.

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Stellar Telemetry

Multichannel implantable telemetry for In-vivo monitoring of physiological parameters.

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NeuroLux

Wireless battery-free optogenetics system for freely moving animals in any setup.

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IntelliCage blog posts

Delving Deeper: IntelliCage Fat Mouse Corner and its Impact on Obesity Research

Obesity, a global health concern, presents a significant risk factor for cognitive decline and neurodegenerative diseases. Preclinical research utilizing obese mouse models plays a crucial…

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Exploring Cognitive Aging: Insights from different Studies in Rodent Models Using the IntelliCage System

Life expectancy has increased greatly over the last decades, but it has been associated with a progressive rise in the incidence of age-related diseases, including…

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The Power of The Hippocampus: Uncovered Stress-Induced Memory Enhancements

The exciting study titled “Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements” Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements | Journal of Neuroscience (jneurosci.org) explores the intricate link…

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IntelliCage

Automated Group Housing with Individual Monitoring

Hardware Blueprint for Diverse Experiments

Benefits Compared to Classical Behavioral Systems

Locomotor and Exploratory Activity

Spatial Learning

Social Behavior

Locomotor and Exploratory Activity

Spatial Learning

Social Behavior

Why Scientist Switch to IntelliCage?

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Dark Tunnel Box – Natural Shelter for Better IntelliCage Data

Why Scientists Choose the Dark Tunnel Box?

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IntelliCage Software – Powering Smarter, Faster Behavioral Research

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Compatible with

Running Wheels

PhenoMaster NG

Stellar Telemetry

NeuroLux

Center of Knowledge

IntelliCage blog posts

Delving Deeper: IntelliCage Fat Mouse Corner and its Impact on Obesity Research

Exploring Cognitive Aging: Insights from different Studies in Rodent Models Using the IntelliCage System

The Power of The Hippocampus: Uncovered Stress-Induced Memory Enhancements

Elevate Your Research. Start Today.