Comparison diagram: classical single-session cognitive testing in isolated novel apparatus versus longitudinal home-cage testing in group-housed mice Funnel diagram showing over 400 Alzheimer's drug compounds tested in mice narrowing to fewer than 5 with human clinical efficacy

15.07.2026 – 4min

Why Alzheimer's Mouse Models Show Cognitive Rescue That Doesn't Translate

Over 400 drugs have rescued cognition in Alzheimer’s mouse models. Fewer than 5 have shown efficacy in humans (Langness et al., 2025). That gap is...

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IntelliCage automated home-cage behavioral testing system with group-housed mice and RFID-equipped operant conditioning corners

19.06.2026 – 9min

8 Drug Classes Tested in IntelliCage: What Group-housed Cognitive Phenotyping Revealed that Standard Tests Missed

IntelliCage is an automated home-cage behavioral testing system developed by TSE Systems. It enables continuous cognitive phenotyping of group-housed rodents using RFID individual identification and...

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LinkedIn post by TSE Systems about behavioral phenotyping. Image shows gloved hands holding a pipette over a sample in a laboratory setting. Text reads: 'The Best Data Comes From Animals That Don't Know They're Being Tested' with subtitle 'A principle for behavioral phenotyping that changes what you measure.' Cyan 'Best Practices' badge in top right corner

13.05.2026 – 2min

How Handling Stress Contaminates Behavioral Data and What to do Instead

There is a confounder in almost every behavioral neuroscience study that nobody mentioned  in the methods section. Handling stress. The moment you pick up an...

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**Alt text:** Schematic summary of a 2026 Molecular Cell study from Prof. Christian Wolfrum’s lab describing MEDAG as a molecular regulator of adipocyte metabolism. The figure illustrates MEDAG (mesenteric estrogen-dependent adipogenesis gene) acting as an A-kinase anchoring protein (AKAP) that binds the regulatory subunit PKA-RIIβ to organize protein kinase A (PKA) signaling complexes in fat cells. A feedback loop is shown in which activated PKA phosphorylates MEDAG, and phosphorylated MEDAG helps restrain further PKA activity, limiting signaling intensity. In adipocyte-specific Medag knockout mice, loss of this restraint leads to increased PKA activity, higher energy expenditure, protection from diet-induced obesity, and a shift toward increased carbohydrate utilization without changes in food intake or physical activity. Whole-body metabolic changes were measured using indirect calorimetry in the PhenoMaster system from TSE Systems, confirming increased energy dissipation in adipose tissue.

20.04.2026 – 2min

A Newly Discovered Molecular Brake on Fat Metabolism: The Role of MEDAG

A recent study from Prof. Christian Wolfrum’s lab, published in Molecular Cell (2026), provides compelling new insights into how adipose tissue regulates energy balance. At...

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Maternal Immune Activation as a Neurodevelopmental Risk Factor: New Insights into ADHD-Like Endophenotypes in a Mouse Model

31.03.2026 – 3min

Maternal Immune Activation as a Neurodevelopmental Risk Factor: New Insights into ADHD-Like Endophenotypes in a Mouse Model

Overview Epidemiological evidence consistently links maternal infection during pregnancy to elevated offspring risk for neurodevelopmental disorders, including ADHD, schizophrenia, and autism spectrum disorder. Yet the...

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