Exercise Respirometry

The TSE CaloTreadmill System is a fully computerized electronically controlled system to investigate exercise calorimetry in mice and rats. CaloTreadmills are enclosed by an air-tight transparent housing that can be connected to a fully automated indirect gas calorimetry system (CaloSys) operated by PhenoMaster software. Calorimetric parameters, such as oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange rate (RQ) and energy expenditure (EE) are determined at fixed temporal intervals while the test animal is moving according to an experimenter-defined activity profile.

Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP. Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 2020; 40: 101028.

Slater RE, Strom JG, Methawasin M, Liss M, Gotthardt M, Sweitzer N, Granzier HL. Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance. J Gen Physiol 2019; 151(1): 42-52.

Brynnel A, Hernandez Y, Kiss B, Lindqvist J, Adler M, Kolb J, van der Pijl R, Gohlke J, Strom J, Smith J, Ottenheijm C, Granzier HL. Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy. Elife 2018; 7: e40532.

Molinero A, Fernandez-Perez A, Mogas A, Giralt M, Comes G, Fernandez-Gayol O, Vallejo M, Hidalgo J. Role of muscle IL-6 in gender-specific metabolism in mice. PLoS One 2017; 12(3):e0173675.

Cavalera M, Axling U, Berger K, Holm C. Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue. Nutr Metab (Lond) 2016; 13:91.

Fentz J, Kjøbsted R, Birk JB, Jordy AB, Jeppesen J, Thorsen K, Schjerling P, Kiens B, Jessen N, Viollet B, Wojtaszewski JF. AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice. FASEB J 2015; 29(5): 1725-38.


Device for high precision calorimetry exercise evaluation in rats and mice.
Air tight compartment for high accuracy respirometry.


Exercise Calorimetry .

Disease models