Hypoxia Applications
Measurement of respiratory parameters
Duivenvoorde, et al. 2014. Pflügers Archiv - European Journal of Physiology
PhenoMaster can also be used to measure respiratory parameters under different environmental conditions. For example, the simulation of high altitudes where the partial oxygen pressure is lower. Since oxygen is a key component in aerobic respiration, metabolic flexibility is different under hypoxic conditions. The Phenomaster allows for several solutions to use synthetic air with customized cages and/or isolators to mimic these special environments. Please contact sales to discuss specific applications.
Hoevenaars FPM, Keijer J, van der Stelt I, Duivenvoorde LPM, Herreman L, van Nes R, Friedecký D, Hegeman MA, van Schothorst EM. White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation. Genes (Basel) 2019; 10(5): 359.
Duivenvoorde LP, van Schothorst EM, Derous D, van der Stelt I, Masania J, Rabbani N, Thornalley PJ, Keijer J. Oxygen restriction as challenge test reveals early high-fat-diet-induced changes in glucose and lipid metabolism. Pflugers Arch 2015; 467(6): 1179-93.