Alabama Tissue Slicer (formerly Krumdieck)

Automated Ex-Vivo Precision Slicing

The Alabama MD6000 Tissue Slicer (formerly Krumdieck) is a high-precision instrument engineered for producing viable, aseptic, and reproducible tissue slices used in biochemical, pharmacological, toxicological, and metabolic research.
Built from polished stainless steel and designed for contamination-free operation, it enables scientists to prepare precision-cut liver, kidney, heart, brain, and adipose tissue slices with exceptional consistency.

Designed for Viability, Accuracy, and Ease of Use

10 µm precision and reproducibility — delivers uniform sections from 50 to 500 µm for reliable quantitative assays.

Aseptic slicing environment — contamination-free chamber and sterilizable components ensure long-term slice culture viability.

Low vibration & smooth motion — linear motor and counter-balanced drive shaft guarantee minimal tissue damage.

Digital touchscreen control — intuitive one-touch operation with independent control of arm and blade speed.

Rapid slice preparation — generate 200–250 consistent slices per rat liver for drug metabolism or toxicity studies.

Supports long-term slice vitality — optimized buffer circulation and temperature control prevent hypoxia and mechanical stress.

Scientific illustration of the precision-cut liver slice (PCLS) workflow showing tissue coring, slicing with the Krumdieck Tissue Slicer in buffer at 4 °C, and subsequent culture of 250 µm liver slices in 12-well plates for ex vivo drug metabolism and toxicology research, as published in the Journal of Hepatology (EASL).

Scientifically Validated for Precision-Cut Liver Slices (PCLS)

Pioneering studies published in the Journal of Hepatology (EASL) and Nature Protocols demonstrate that the Alabama Tissue Slicer enables the preparation of precision-cut liver slices (PCLS) — a reliable ex vivo model bridging the gap between in vitro assays and in vivo studies.
Researchers have used this system to generate 200–250 uniform slices per rat liver with consistent 250 µm thickness, maintained in culture under physiological conditions for several days.

This model is now widely adopted for investigating metabolic function, drug toxicity, fibrosis, and hepatocellular responses, confirming the instrument’s role in translational research.

Available Accessories

Tissue Embedding Unit

Tissue Slice Thickness Gauge

Tissue Coring Press

Incubation Unit

Recirculating Refrigeration Bath

Different size Tissue Coring Tools

Gold Standard for Precision-Cut Tissue Slices (PCTS)

Performing precision cutting of delicate organs such as liver, kidney, lung or tumour in a continuously circulating buffer environment provides optimal physiological conditions for ex vivo tissue preparation.
The Alabama MD6000 Tissue Slicer is specifically engineered for buffer-submerged slicing, preserving the structural and functional integrity of live tissues throughout the process.

Advantages of slicing in a buffer solution include:
• Preservation of tissue integrity and pH stability during cutting
• Minimized cellular stress and mechanical damage
• Prevention of oxidative stress through continuous oxygenation and cooling
• Maintenance of cellular metabolism and viability for long-term ex vivo studies

Publications

Kim, K.H., Kim, J., Han, J.Y. et al. In vitro estimation of metal-induced disturbance in chicken gut-oviduct chemokine circuit. Mol. Cell. Toxicol. 15, 443–452 (2019).

Ramzan, A.A., Bitler, B.G., Hicks, D. et al. Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells. Mol Cell Biochem 461, 37–46 (2019).

Fu, Y., Tong, J., Meng, F. et al. Ciliostasis of airway epithelial cells facilitates influenza A virus infection. Vet Res 49, 65 (2018).