Spatial Learning & Memory
Radial Mazes (8-Arm Mazes) are used to investigate hippocampus-dependent learning and memory performance in rodents. In the usual task, food is available at the end of each arm or in selected arms only. The animal has to learn to visit each baited arm once without going back to an already-visited empty arm or entering an arm that has never been baited. Learning and memory impairments will influence the performance in subsequent retention tests.
The TSE Radial Mazes are used in combination with a video-tracking system such as the TSE VideoMot2 system. Several sizes and colors are available. A support frame can be combined with the maze for comfortable handling. Special IR translucent mazes allow tracking of animals under each light conditions – even in complete darkness – when they are combined with the TSE IR-Boxes
During the experiment, the tracking system registers animal movement in the maze. Arm visits and visits to food troughs are detected according to user-defined zones. Control regions can be defined to control the experiment, e.g. stop the experiment after all baited arms have been visited. The event recorder is available to add behaviors to the tracking data that cannot be detected automatically. In the Radial Maze protocol, the number of correct choices, i.e. first entries into baited arms, as well as performance errors (Working and Reference memories) are calculated. The maze also can be run with non-baited arms to monitor the locomotion pattern in the maze.