The Tail Suspension test is a rapid and easy-to-use test to study the acute effects of antidepressants. When rodents are suspended by their tails (inescapable stress), they alternate between agitation and immobility. The duration of immobility as a measure for behavioral despair is typically measured in a 6-minute session. Antidepressants reduce the total time of immobility and increase the latency to immobility.
The TSE Tail Suspension Monitor registers animal movement with a sensitive force sensor that is built into a test enclosure shielding the animal from the environment. Up to 8 measuring places can be operated in parallel – each measuring place can be started individually as soon as the animal has been fixed to the sensor. The movement picked up by the sensor is transmitted into the TSE Tail Suspension software and displayed as a continuous movement waveform so that the status of each animal can be seen at a glance. Time of immobility is calculated in real-time for adjustable time bins by taking a user-defined activity threshold into account. Values are stored together with the total time of mobility and movement amplitude in results files that are ready-to-use for further statistical evaluation.