Krumdieck Tissue Slicer

Automated Ex-Vivo Precision Slicing

Precision-cut tissue slices mimic the multicellular characteristics of organs in vivo. The Krumdieck Tissue Slicer provides samples of uniform and reproducible thickness, minimizes damage to surfaces of slices and thereby eliminates the main sources of error in tissue slice work.

The slicer operates submerged in a buffer which provides a lubricated environment that facilitates smooth and precise cutting of tissue sections. A motor-driven and rapidly reciprocating disposable blade oscillating at 1000 to 2500 rpm, cuts precision slices from approximately 100 to 500 microns in thickness.

System benefits

Operates submerged in a buffer solution to protect the tissue

Measures with an accuracy of 10 microns

Only commercially available sterilizable microtome

Available Accessories

Tissue Embedding Unit

Tissue Slice Thickness Gauge

Tissue Coring Press

Incubation Unit

Recirculating Refrigeration Bath

Different size Tissue Coring Tools

Gold Standard for PCTS

Precision cutting of tissue samples, especially from delicate organs like the liver and lung, can benefit significantly from being done in a buffer solution. The Krumdieck Tissue Slicer is the only slicer on the market that offers this functionality to obtain high-quality tissue sections suitable for various analytical and experimental purposes.

Performing precision cutting of liver and lung tissue samples in a buffer solution offers several advantages, including:

– Preservation of tissue Integrity by maintaining the pH balance of the tissue

– Minimization of cellular stress and damage

– Prevention of oxidative stress

– Maintenance of cellular function by providing essential nutrients and ions


This product is not available through TSE Systems in the North American market.

Publications

Kim, K.H., Kim, J., Han, J.Y. et al. In vitro estimation of metal-induced disturbance in chicken gut-oviduct chemokine circuit. Mol. Cell. Toxicol. 15, 443–452 (2019).

Ramzan, A.A., Bitler, B.G., Hicks, D. et al. Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells. Mol Cell Biochem 461, 37–46 (2019).

Fu, Y., Tong, J., Meng, F. et al. Ciliostasis of airway epithelial cells facilitates influenza A virus infection. Vet Res 49, 65 (2018).