Your global trusted partner for preclinical in-vivo research

High-throughput phenotyping systems for mice and rats, supporting research in metabolism, behavior, physiology and inhalation through fully automated, modular platforms.

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139 +

Years of Innovation

4000 +

Research Group Users

54

Countries Served

6560 +

Scientific Publications

TSE Systems - Your global trusted partner

Welcome to TSE Systems

For over 136 years, TSE Systems has been at the forefront of preclinical research innovation. We understand the evolving needs of researchers and are dedicated to developing sophisticated equipment for animal studies in Metabolism, Behavior, Physiology & Inhalation. Our commitment goes beyond technology.

Acknowledging the challenges of in-vivo animal research we champion the 3Rs (Replacement, Reduction, Refinement) and design high-throughput solutions to maximize data output while minimizing resource strain and data variability. This, paired with intuitive software analysis, allows us to streamline your workflow and save your valuable time.

Discover Our Key Products

PhenoMaster NG

Metabolic cage system for mouse, rat or larger animals. Suitable for calorimetry, behavioral and physiological studies.

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IntelliCage, automated behavioral assessment, home cage monitoring, mice, rats, social interaction, enriched environment, cognitive performance, animal welfare, minimal handling, high reproducibility, standardized setup, animal gate, controlled access, RFID identification, programmable protocols, running wheels, metabolic cages, stress reduction, research workflow.

IntelliCage

Fully automated system for group-housed rodent behavioral and cognitive phenotyping allowing to preserve social environment.

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MotoRater

Rodent kinematic gait analysis system, allowing assessment of fine locomotor patterns in both rats and mice, during 5 different motion modalities.

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Inhalation System

Head-nose and Whole-body systems for dust, liquid aerosol, vapor, cigarette smoke, and nanoparticle generation in toxicology and safety studies.

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Multi Conditioning System

First multi-purpose turnkey platform for up to 10 rodent behavioral tests, from Fear Conditioning to Open Field in a fully controlled environment.

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Stellar Telemetry

Multichannel implantable telemetry for In-vivo monitoring of physiological parameters.

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Expert Guidance Every Step of the Way

Discuss your goals with our research-focused sales scientists. We’ll then connect you with product managers and engineers to guide you toward a configuration and protocols, that can fulfill your scientific needs.

Need a custom solution? No problem. We’ll work with you to craft the perfect fit for your unique preclinical research needs.

Your Research Journey Starts Here.

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“I have been using products from TSE to measure metabolic phenotypes in mice since 2006 when I was a trainee. I love TSE products because they provide reliable measurements and more importantly TSE kept improving and innovating their products to help us push the edge of science.”

Yong Xu
Professor | Baylor College of Medicine

Trusted by Scientists Worldwide

Meet Us Next

Neuroscience TSE Systems

Fens Forum 2026

Join TSE Systems at booth booth #98 and thousands of neuroscientists in Barcelona from 6–10 July 2026 for Europe’s premier international neuroscience meeting. By submitting your abstract,…

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Society for Neuroscience (SfN) 2026

Meet us at SFN on November 14–Wednesday, November 18 – booth #1501. Founded in 1969, the Society for Neuroscience (SfN) has over 30,000 members in…

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13th Helmholtz Diabetes Conference 

13th Helmholtz Diabetes Conference 

Meet us at the 13th Helmholtz Diabetes Conference on 21 – 23 September in Munich that brings together leading international scientists to discuss the latest advances in “Diabetes…

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6th Metabolic Diseases: Breakthrough Discoveries in Diabetes & Obesity

6th Metabolic Diseases: Breakthrough Discoveries in Diabetes & Obesity

Meet us at 6th Metabolic Diseases: Breakthrough Discoveries in Diabetes & Obesity where our devices will be showcased at the booth of our distributor AiMedical.

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24th Fraunhofer Seminar Models of Lung Disease

24th Fraunhofer Seminar Models of Lung Disease

Meet us at the latest scientific findings, top-class lectures and a wide range of opportunities for professional exchange in the 24th Fraunhofer Seminar Models of…

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Scientific Insights

**Alt text:** Schematic summary of a 2026 Molecular Cell study from Prof. Christian Wolfrum’s lab describing MEDAG as a molecular regulator of adipocyte metabolism. The figure illustrates MEDAG (mesenteric estrogen-dependent adipogenesis gene) acting as an A-kinase anchoring protein (AKAP) that binds the regulatory subunit PKA-RIIβ to organize protein kinase A (PKA) signaling complexes in fat cells. A feedback loop is shown in which activated PKA phosphorylates MEDAG, and phosphorylated MEDAG helps restrain further PKA activity, limiting signaling intensity. In adipocyte-specific Medag knockout mice, loss of this restraint leads to increased PKA activity, higher energy expenditure, protection from diet-induced obesity, and a shift toward increased carbohydrate utilization without changes in food intake or physical activity. Whole-body metabolic changes were measured using indirect calorimetry in the PhenoMaster system from TSE Systems, confirming increased energy dissipation in adipose tissue.

A Newly Discovered Molecular Brake on Fat Metabolism: The Role of MEDAG

A recent study from Prof. Christian Wolfrum’s lab, published in Molecular Cell (2026), provides compelling new insights into how adipose tissue regulates energy balance. At…

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Maternal Immune Activation as a Neurodevelopmental Risk Factor: New Insights into ADHD-Like Endophenotypes in a Mouse Model

Maternal Immune Activation as a Neurodevelopmental Risk Factor: New Insights into ADHD-Like Endophenotypes in a Mouse Model

Overview Epidemiological evidence consistently links maternal infection during pregnancy to elevated offspring risk for neurodevelopmental disorders, including ADHD, schizophrenia, and autism spectrum disorder. Yet the…

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PhenoMaster - Polyagonist Therapies in Obesity

Polyagonist Therapies in Obesity: A systems-level case study enabled by continuous in vivo phenotyping

Introduction  Obesity and type 2 diabetes are not single-pathway diseases. They emerge from a complex disruption of whole-body energy homeostasis involving the gut, brain, pancreas,…

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MotoRater Translational Relevance: From Rodents to Humans

From Preclinical Motion to Clinical Insight: Bridging the Translational Gap with 3D Kinematic Gait Analysis

Motor function is a critical parameter  in CNS drug development. Subtle changes in gait and posture often precede overt clinical symptoms in neurological and neurodegenerative…

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The Rhythm of Life: Prof. Paul Petrus on How Our Body’s Clock Shapes Metabolism and Health

Join us for an exclusive interview with Prof. Paul Petrus from the Petrus Lab. His research focuses on endocrinology and diabetes, with a particular interest…

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The Expanding Impact of PhenoMaster: Fueling Scientific Discovery

PhenoMaster. A story of Scientific Trust.

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