IntelliCage

New Standard for Rodents Behavioral & Cognitive Phenotyping

System Architecture
Unique features
Paradigms
Software
Publications
Compatible with
Center of knowledge
News

Automated Group Housing with Individual Data Collection

IntelliCage is a fully automated system allowing you to assess home cage behavior and cognitive performance of up to 16 mice or 8 rats respectively while preserving social interaction. This unique experimental setup fosters natural social behavior in a biologically relevant, enriched and highly standardized home cage context. Therefore, IntelliCage minimizes handling and human intervention, increasing task validity, data reproducibility and ensuring a high level of animal welfare.

To provide a greater control over animal movement between the IntelliCage and external compartments, like running wheels or metabolic cages, we offer our sophisticated animal gate. Conditionally manage access based on individual animal identification and programmable protocols, streamline your research workflows while minimizing stress on your subjects.

Request a Quote

Hardware Blueprint for Diverse Experiments

Benefits Compare to Classic Systems

The IntelliCage system is a versatile platform for studying a broad spectrum of rodent behaviors. From spontaneous activity/circadian rhythms to spatial preferences/corner exploration patterns, or intricate patrolling behaviors, IntelliCage offers a comprehensive overview. This innovative system promotes greater data consistency across laboratories compared to traditional method. IntelliCage measures similar traits assessed in classic open-field tests and Morris water maze experiments, excelling in exploration and locomotor activity analysis. Automated and standardized measurements ensure higher data reproducibility across labs, allowing researchers to focus on interpreting meaningful behavioral patterns.

Locomotor and Exploratory Activity

The IntelliCage excels in exploratory behavior and locomotor activity assessments compared to traditional tests. Classic methods show data variability, leading to complex strain-by-laboratory interactions. IntelliCage providis automated and standardized measurements, ensuring higher data reproducibility accross sdifferent labs.

Spatial Learning

The system effectively measures spatial learning through paradigms similar to the Morris water maze test, but with significant time-saving benefits. Our research demonstrates a remarkable decrease in workload – up to 40 times faster than traditional methods – allowing researchers to conduct more experiments and expedite discoveries.

Social Behavior

IntelliCage facilitates the exploration of social interactions between rodents. By capturing parameters like spatial preferences and corner visitation patterns, researchers can gain valuable insights into social dynamics and communication within rodent groups.

Locomotor and Exploratory Activity

Modified from Lipp et al., 2005

Spatial Learning

Social Behavior

Unique features

Group Housing of 16 Mice or 8 Rats in a Social Home Cage Environment

24/7 Continuous Testing During Light/Dark Phases for Days or Weeks

Transfer of Validated Behavioral Paradigms into an Automated Setup

Reduced Required Resources: Multiple Paradigms & Minimum Human Interference

High Throughput Screening: accommodates 64 mice or 32 rats across four cages

Customizable Experimental Setups

Diverse Behavioral Paradigms

Spontaneous Behavior

Spatial and Temporal Behavior

Discrimination Learning and Preferences

Social Interaction, including Competition and Hierarchy Analysis

Operant Conditioning

Diverse Learning and Memory tasks

IntelliCage Software for Efficient Studies

The IntelliCage software suite offers a comprehensive solution for researchers conducting automated behavioral studies in a social environment. Comprised of three distinct modules, this software facilitates efficient experimental design, precise execution, and robust data analysis.

Cluster Configuration
Behavioral Event Mapping
Graphical User Interface
Modular Flexibility
Automated Day Patterns

Defines the parameters of experimental hardware configuration.
Creates a comprehensive list of individual specifics, including ID, transponder number, sex, group, and assigned cluster.
Crafts experimental designs with one or multiple phases tailored to research needs.

Captures and stores behavioral events (visits, nose pokes, licks) and environmental data (lighting, temperature) from the sensor data stream.
Allows real-time monitoring of data from various sensors and actors.
Tracks individual animal behavioral parameters in graphs.
Enables alerts when specific animals show no visits or licks during designated periods.

Filters data with boolean reporters to focus on specific timing or conditions.
Evaluates filtered data with access to the original dataset.
Offers applied filters for future analyses across multiple experiments.
Saves image files in various formats.
Allows data export for analyses in statistic programs.

Publications

Kahnau, P., Jaap, A., Diederich, K., Gygax, L., Rudeck, J., & Lewejohann, L. (2023). Determining the value of preferred goods based on consumer demand in a home-cage based test for mice. Behavior Research Methods, 55(2), 751–766.

Kiryk, A., Janusz, A., Zglinicki, B., Turkes, E., Knapska, E., Konopka, W., Lipp, H.-P., & Kaczmarek, L. (2020). IntelliCage as a tool for measuring mouse behavior – 20 years perspective. Behavioural Brain Research, 388, 112620.

Mohammadi, F., Bertrand, N., & Rudkowska, I. (2023). C57bl/6 Mice Show Equivalent Taste Preferences toward Ruminant and Industrial Trans Fatty Acids. Nutrients, 15(3), Article 3.

Pagano, R., Salamian, A., Zielinski, J., Beroun, A., Nalberczak-Skóra, M., Skonieczna, E., Cały, A., Tay, N., Banaschewski, T., Desrivières, S., Grigis, A., Garavan, H., Heinz, A., Brühl, R., Martinot, J.-L., Martinot, M.-L. P., Artiges, E., Nees, F., Orfanos, D. P., … Radwanska, K. (2023). Arc controls alcohol cue relapse by a central amygdala mechanism. Molecular Psychiatry, 28(2), Article 2.

Plum, T., Binzberger, R., Thiele, R., Shang, F., Postrach, D., Fung, C., Fortea, M., Stakenborg, N., Wang, Z., Tappe-Theodor, A., Poth, T., MacLaren, D. A. A., Boeckxstaens, G., Kuner, R., Pitzer, C., Monyer, H., Xin, C., Bonventre, J. V., Tanaka, S., … Rodewald, H.-R. (2023). Mast cells link immune sensing to antigen-avoidance behaviour. Nature, 1–9.

Francesca Morello, Vootele Voikar, Pihla Parkkinen, Anne Panhelainen, Marko Rosenholm, Aki Makkonen, Tomi Rantamäki, Petteri Piepponen, Teemu Aitta-aho & Juha Partanen. Transl Psychiatry, vol. 10, no. 1, Art. no. 1, Oct. 2020, doi: 10.1038/s41398-020-01033-8.

Małgorzata Alicja Śliwińska, Anna Cały, Malgorzata Borczyk, Magdalena Ziółkowska, Edyta Skonieczna, Magdalena Chilimoniuk, Tytus Bernaś, K Peter Giese & Kasia Radwanska. Cerebral Cortex, vol. 30, no. 4, pp. 2573–2585, Apr. 2020, doi: 10.1093/cercor/bhz261.

Marzena Stefaniuk, Anna Beroun, Tomasz Lebitko, Olga Markina, Szymon Leski, Ksenia Meyza, Anna Grzywacz, Jerzy Samochowiec, Agnieszka Samochowiec, Kasia Radwanska & Leszek Kaczmarek. Biological Psychiatry, vol. 81, no. 11, pp. 907–917, Jun. 2017, doi: 10.1016/j.biopsych.2016.12.026.

F Cathomas, M Stegen, H Sigrist, L Schmid, E Seifritz, M Gassmann, B Bettler & C R Pryce. Transl Psychiatry, vol. 5, no. 2, Art. no. 2, Feb. 2015, doi: 10.1038/tp.2015.8.

Marta Perez-Alcazar, Jonny Daborg, Anna Stokowska, Pontus Wasling, Andreas Björefeldt, Marie Kalm, Henrik Zetterberg, Karl E. Carlström, Klas Blomgren, Christine T. Ekdahl, Eric Hanse & Marcela Pekna. Experimental Neurology, vol. 253, pp. 154–164, Mar. 2014, doi: 10.1016/j.expneurol.2013.12.013.

Anna Kiryk, Tomomi Aida, Kohichi Tanaka, Pradeep Banerjee, Grzegorz M Wilczynski, Ksenia Meyza, Ewelina Knapska, Robert K Filipkowski, Leszek Kaczmarek & Wojciech Danysz. Neurotox Res, vol. 13, no. 1, pp. 19–30, Jan. 2008, doi: 10.1007/BF03033364.

Vadim Alexandrov, Dani Brunner, Liliana B Menalled, Andrea Kudwa, Judy Watson-Johnson, Matthew Mazzella, Ian Russell, Melinda C Ruiz, Justin Torello, Emily Sabath, Ana Sanchez, Miguel Gomez, Igor Filipov, Kimberly Cox, Mei Kwan, Afshin Ghavami, Sylvie Ramboz, Brenda Lager, Vanessa C Wheeler, Jeff Aaronson, Jim Rosinski, James F Gusella, Marcy E MacDonald, David Howland & Seung Kwak. Nat Biotechnol, vol. 34, no. 8, Art. no. 8, Aug. 2016, doi: 10.1038/nbt.3587.

Danielle A. Simmons, Nadia P. Belichenko, Ellen C. Ford, Sarah Semaan, Marie Monbureau, Sruti Aiyaswamy, Cameron M. Holman, Christina Condon, Mehrdad Shamloo, Stephen M. Massa & Frank M. Longo. Human Molecular Genetics, vol. 25, no. 22, pp. 4920–4938, Nov. 2016, doi: 10.1093/hmg/ddw316.

F. Balci et al. PLoS Curr, 2013, doi: 10.1371/currents.hd.124aa0d16753f88215776fba102ceb29.

Liliana B. Menalled, Andrea E. Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell, David Connor, Carol Murphy, Steve Oakeshott, Mei Kwan, Jose Beltran, Afshin Ghavami, Dani Brunner, Larry C. Park, Sylvie Ramboz & David Howland. PLOS ONE, vol. 7, no. 12, p. e49838, Dec. 2012, doi: 10.1371/journal.pone.0049838.

Stephen Oakeshott, Fuat Balci, Igor Filippov, Carol Murphy, Russell Port, David Connor, Ahmad Paintdakhi, Joseph LeSauter, Liliana Menalled, Sylvie Ramboz, Seung Kwak, David Howland, Rae Silver & Dani Brunner. PLoS Curr, vol. 3, p. RRN1225, Apr. 2011, doi: 10.1371/currents.RRN1225.

Maria A. Tikhonova, Tamara G. Amstislavskaya, Ying-Jui Ho, Anna A. Akopyan, Michael V. Tenditnik, Marina V. Ovsyukova, Alim A. Bashirzade, Nina I. Dubrovina & Lyubomir I. Aftanas. Frontiers in Neuroscience, vol. 15, 2021, Accessed: Oct. 25, 2023. [Online].

Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C. J. Hofmann, Mike Schmidt, Takashi Saito, Takaomi C. Saido, Robert Gurke, Dominik Schmidt, Uwe Till, Michael J. Parnham & Gerd Geisslinger. Nutrients, vol. 12, no. 11, Art. no. 11, Nov. 2020, doi: 10.3390/nu12113248.

A. Masuda, Y. Kobayashi, N. Kogo, T. Saito, T. C. Saido, and S. Itohara. Neurobiology of Learning and Memory, vol. 135, pp. 73–82, Nov. 2016, doi: 10.1016/j.nlm.2016.07.001.

D. Ryan, D. Koss, E. Porcu, H. Woodcock, L. Robinson, B. Platt & G. Riedel. Cell. Mol. Life Sci., vol. 70, no. 14, pp. 2603–2619, Jul. 2013, doi: 10.1007/s00018-013-1314-4.

Sascha W Weyer, Maja Klevanski, Andrea Delekate, Vootele Voikar, Dorothee Aydin, Meike Hick, Mikhail Filippov, Natalia Drost, Kristin L Schaller, Martina Saar, Miriam A Vogt, Peter Gass, Ayan Samanta, Andres Jäschke, Martin Korte, David P Wolfer, John H Caldwell, and Ulrike C Müller. The EMBO Journal, vol. 30, no. 11, pp. 2266–2280, Jun. 2011, doi: 10.1038/emboj.2011.119.

Alina Codita, Astrid Gumucio, Lars Lannfelt, Pär Gellerfors, Bengt Winblad, Abdul H. Mohammed & Lars N.G. Nilsson. Behavioural Brain Research, vol. 215, no. 1, pp. 83–94, Dec. 2010, doi: 10.1016/j.bbr.2010.06.034.

J. Y. Holgate, H. Garcia, S. Chatterjee, and S. E. Bartlett. Brain and Behavior, vol. 7, no. 8, p. e00767, 2017, doi: 10.1002/brb3.767.

N. I. W. Ismail, N. Jayabalan, S. M. Mansor, C. P. Müller, and M. Muzaimi. Addiction Biology, vol. 22, no. 4, pp. 967–976, 2017, doi: 10.1111/adb.12385.

Jan Rodriguez Parkitna, Magdalena Sikora, Sławomir Gołda, Krystyna Gołembiowska, Beata Bystrowska, David Engblom, Ainhoa Bilbao & Ryszard Przewlocki. Biological Psychiatry, vol. 73, no. 3, pp. 263–270, Feb. 2013, doi: 10.1016/j.biopsych.2012.07.019.

Ewelina Knapska, Victoria Lioudyno, Anna Kiryk, Marta Mikosz, Tomasz Górkiewicz, Piotr Michaluk, Maciej Gawlak, Mayank Chaturvedi, Gabriela Mochol, Marcin Balcerzyk, Daniel K. Wojcik, Grzegorz M. Wilczynski and Leszek Kaczmarek. J. Neurosci., vol. 33, no. 36, pp. 14591–14600, Sep. 2013, doi: 10.1523/JNEUROSCI.5239-12.2013.

M. Piechota, M. Korostynski, M. Sikora, S. Golda, J. Dzbek, and R. Przewlocki. Genes, Brain and Behavior, vol. 11, no. 4, pp. 404–414, 2012, doi: 10.1111/j.1601-183X.2012.00777.x.

K. Radwanska and L. Kaczmarek. Addiction Biology, vol. 17, no. 3, pp. 601–612, 2012, doi: 10.1111/j.1369-1600.2011.00394.x.

Kazuhiro Sano, Tomohiko Isobe,Jiaxin Yang, Tin-Tin Win-Shwe, Mitsuha Yoshikane, Shoji F. Nakayama, Takaharu Kawashima, Go Suzuki, Shunji Hashimoto, Keiko Nohara, Chiharu Tohyama & Fumihiko Maekawa. Frontiers in Neuroscience, vol. 10, 2016, Accessed: Nov. 08, 2023. [Online]. Available: https://www.frontiersin.org/articles/10.3389/fnins.2016.00228.

Lei Xing https://orcid.org/0000-0003-0542-4083, Agnieszka Kubik‐Zahorodna https://orcid.org/0000-0002-2331-3814, Takashi Namba, Anneline Pinson, Marta Florio, Jan Prochazka, Mihail Sarov, Radislav Sedlacek, and Wieland B Huttner. The EMBO Journal, vol. 40, no. 13, p. e107093, Jul. 2021, doi: 10.15252/embj.2020107093.

S. Schroeder et al. Cell Reports, vol. 35, no. 2, p. 108985, Apr. 2021, doi: 10.1016/j.celrep.2021.108985.

Tomoaki M. Kato, Mie Kubota-Sakashita, Noriko Fujimori-Tonou, Fumihito Saitow, Satoshi Fuke, Akira Masuda, Shigeyoshi Itohara, Hidenori Suzuki & Tadafumi Kato. Mol Psychiatry, vol. 23, no. 10, Art. no. 10, Oct. 2018, doi: 10.1038/s41380-018-0074-9.

A. Masuda, Y. Kobayashi, N. Kogo, T. Saito, T. C. Saido, and S. Itohara. Neurobiology of Learning and Memory, vol. 135, pp. 73–82, Nov. 2016, doi: 10.1016/j.nlm.2016.07.001.

M Heidari, D M Johnstone, B Bassett, R M Graham, A C G Chua, M J House, J F Collingwood, C Bettencourt, H Houlden, M Ryten, J K Olynyk, D Trinder & E A Milward. Mol Psychiatry, vol. 21, no. 11, Art. no. 11, Nov. 2016, doi: 10.1038/mp.2015.192.

Katharina Gapp, Saray Soldado-Magraner, María Alvarez-Sánchez, Johannes Bohacek, Gregoire Vernaz, Huan Shu, Tamara B. Franklin, David Wolfer & Isabelle M. Mansuy. Nat Commun, vol. 5, no. 1, Art. no. 1, Nov. 2014, doi: 10.1038/ncomms6466.

Toshihiro Endo, Masaki Kakeyama, Yukari Uemura, Asahi Haijima, Hiroyuki Okuno, Haruhiko Bito & Chiharu Tohyama. PLOS ONE, vol. 7, no. 12, p. e50741, Dec. 2012, doi: 10.1371/journal.pone.0050741.

Elena Deliu, Niccolò Arecco, Jasmin Morandell, Christoph P. Dotter, Ximena Contreras, Charles Girardot, Eva-Lotta Käsper, Alena Kozlova, Kasumi Kishi, Ilaria Chiaradia, Kyung-Min Noh & Gaia Novarino. Nat Neurosci, vol. 21, no. 12, Art. no. 12, Dec. 2018, doi: 10.1038/s41593-018-0266-2.

M Mitjans, M Begemann, A Ju, E Dere, L Wüstefeld, S Hofer, I Hassouna, J Balkenhol, B Oliveira, S van der Auwera, R Tammer, K Hammerschmidt, H Völzke, G Homuth, F Cecconi, K Chowdhury, H Grabe, J Frahm, S Boretius, T Dandekar & H Ehrenreich. Transl Psychiatry, vol. 7, no. 10, Art. no. 10, Oct. 2017, doi: 10.1038/tp.2017.213.

Kyaw H. Aung, Chaw Kyi-Tha-Thu, Kazuhiro Sano, Kazuaki Nakamura, Akito Tanoue, Keiko Nohara, Masaki Kakeyama, Chiharu Tohyama, Shinji Tsukahara & Fumihiko Maekawa. Frontiers in Neuroscience, vol. 10, 2016, Accessed: Nov. 09, 2023. [Online]. Available: https://www.frontiersin.org/articles/10.3389/fnins.2016.00137

A. Puścian, S. Łęski, T. Górkiewicz, K. Meyza, H.-P. Lipp, and E. Knapska. Frontiers in Behavioral Neuroscience, vol. 8, 2014.

Ger J.A. Ramakers, David Wolfer, Georg Rosenberger, Kerstin Kuchenbecker, Hans-Jürgen Kreienkamp, Janine Prange-Kiel, Gabriele Rune, Karin Richter, Kristina Langnaese, Sophie Masneuf, Michael R. Bösl, Klaus-Dieter Fischer, Harm J. Krugers, Hans-Peter Lipp, Elly van Galen & Kerstin Kutsche. Human Molecular Genetics, vol. 21, no. 2, pp. 268–286, Jan. 2012, doi: 10.1093/hmg/ddr457.

Mehrdad Faizi, Patrick L. Bader, Christine Tun, Angelo Encarnacion, Alexander Kleschevnikov, Pavel Belichenko, Nay Saw, Matthew Priestley, Richard W. Tsien, William C. Mobley & Mehrdad Shamloo. Neurobiology of Disease, vol. 43, no. 2, pp. 397–413, Aug. 2011, doi: 10.1016/j.nbd.2011.04.011.

Silvia Alboni, Silvia Poggini, Stefano Garofalo, Giampaolo Milior, Hassan El Hajj, Cynthia Lecours, Isabelle Girard, Steven Gagnon, Samuel Boisjoly-Villeneuve, Nicoletta Brunello, David P. Wolfer f, Cristina Limatola, Marie-Ève Tremblay, Laura Maggi & Igor Branchi. Mol Psychiatry, vol. 22, no. 4, Art. no. 4, Apr. 2017, doi: 10.1038/mp.2015.142.

J. Y. Holgate, H. Garcia, S. Chatterjee, and S. E. Bartlett. Brain and Behavior, vol. 7, no. 8, p. e00767, 2017, doi: 10.1002/brb3.767.

Giampaolo Milior, Cynthia Lecours, Louis Samson, Kanchan Bisht, Silvia Poggini, Francesca Pagani, Cristina Deflorio, Clotilde Lauro, Silvia Alboni, Cristina Limatola, Igor Branchi, Marie-Eve Tremblay & Laura Maggi. Brain, Behavior, and Immunity, vol. 55, pp. 114–125, Jul. 2016, doi: 10.1016/j.bbi.2015.07.024.

Giorgio Bergamini , Flurin Cathomas , Sandra Auer, Hannes Sigrist, Erich Seifritz, Michael Patterson, Cecilia Gabriel & Christopher R. Pryce. European Neuropsychopharmacology, vol. 26, no. 9, pp. 1448–1464, Sep. 2016, doi: 10.1016/j.euroneuro.2016.06.009.

Morten Jensen, Cecilia Ratner, Olga Rudenko, Søren H. Christiansen, Louise J. Skov, Cecilie Hundahl, David P.D. Woldbye & Birgitte Holst. International Journal of Neuropsychopharmacology, vol. 19, no. 5, p. pyv123, May 2016, doi: 10.1093/ijnp/pyv123.

F Cathomas, M Stegen, H Sigrist, L Schmid, E Seifritz, M Gassmann, B Bettler & C R Pryce. Transl Psychiatry, vol. 5, no. 2, Art. no. 2, Feb. 2015, doi: 10.1038/tp.2015.8.

S. Benner, T. Endo, N. Endo, M. Kakeyama, and C. Tohyama. Physiology & Behavior, vol. 137, pp. 42–52, Oct. 2014, doi: 10.1016/j.physbeh.2014.06.018.

Igor Branchi ,Sara Santarelli, Sara Capoccia, Silvia Poggini, Ivana D’Andrea, Francesca Cirulli & Enrico Alleva. PLOS ONE, vol. 8, no. 4, p. e62226, Apr. 2013, doi: 10.1371/journal.pone.0062226.

I. Branchi, S. Santarelli, I. D’Andrea, and E. Alleva. Hormones and Behavior, vol. 63, no. 3, pp. 503–509, Mar. 2013, doi: 10.1016/j.yhbeh.2013.01.003.

I. Branchi, I. D’Andrea, F. Cirulli, H.-P. Lipp, and E. Alleva. Psychoneuroendocrinology, vol. 35, no. 5, pp. 743–751, Jun. 2010, doi: 10.1016/j.psyneuen.2009.10.016.

Natalia Onishchenko, Christoffer Tamm, Marie Vahter, Tomas Hökfelt, Jeffrey A. Johnson, Delinda A. Johnson & Sandra Ceccatelli. Toxicological Sciences, vol. 97, no. 2, pp. 428–437, Jun. 2007, doi: 10.1093/toxsci/kfl199.

M. Yesiltepe, T. Yin, M. D. Tambini, L. Breuillaud, S. P. Zehntner, and L. D’Adamio. Frontiers in Aging Neuroscience, vol. 14, 2022.

Giulia Cisbani, Silvia Poggini, Nataly Laflamme, Vincent Pons, Marie-Ève Tremblay, Igor Branchi & Serge Rivest. Brain Research, vol. 400, p. 113039, Feb. 2021, doi: 10.1016/j.bbr.2020.113039.

Olga Rudenko, Cecilie Springer, Louisa J. Skov, Andreas N. Madsen, Lis Hasholt, Anne Nørremølle & Birgitte Holst. Journal of Neuroendocrinology, vol. 31, no. 7, p. e12699, 2019, doi: 10.1111/jne.12699.

A. Masuda, Y. Kobayashi, and S. Itohara. JoVE (Journal of Visualized Experiments), no. 138, p. e58009, Aug. 2018, doi: 10.3791/58009.

David J. Koss, Lianne Robinson, Benjamin D. Drever, Kaja Plucińska, Sandra Stoppelkamp, Peter Veselcic, Gernot Riedel & Bettina Platt. Neurobiology of Disease, vol. 91, pp. 105–123, Jul. 2016, doi: 10.1016/j.nbd.2016.03.002.

A. Benraiss et al. Nat Commun, vol. 7, no. 1, Art. no. 1, Jun. 2016, doi: 10.1038/ncomms11758.

V. Alexandrov, D. Brunner, T. Hanania, and E. Leahy. European Journal of Pharmacology, vol. 750, pp. 82–89, Mar. 2015, doi: 10.1016/j.ejphar.2014.11.047.

Fuat Balci, Stephen Oakeshott, Jul Lea Shamy, Bassem F. El-Khodor, Igor Filippov, Richard Mushlin, Russell Port, David Connor, Ahmad Paintdakhi, Liliana Menalled, Sylvie Ramboz, David Howland, Seung Kwak, and Dani Brunner. PLoS Curr, vol. 5, p. ecurrents.hd.124aa0d16753f88215776fba102ceb29, Jul. 2013, doi: 10.1371/currents.hd.124aa0d16753f88215776fba102ceb29.

Xiuhua Li, Yubo Gao, Xu Han, Shaling Tang, Na Li, Xing Liu & Xinli Ni. Experimental Gerontology, vol. 176, p. 112168, Jun. 2023, doi: 10.1016/j.exger.2023.112168.

H. Oizumi, S. Miyazaki, M. Tabuchi, T. Endo, Y. Omiya, and K. Mizoguchi. Frontiers in Pharmacology, vol. 11, 2020.

L. K. Too, A. J. Mitchell, I. S. McGregor, and N. H. Hunt. Brain, Behavior, and Immunity, vol. 56, pp. 68–83, Aug. 2016, doi: 10.1016/j.bbi.2016.01.021.

B. Albuquerque, A. Häussler, E. Vannoni, D. Wolfer, and I. Tegeder. Frontiers in Behavioral Neuroscience, vol. 7, 2013.

Alessandra Berry, Irmgard Amrein, Sarah Nötzli, Stan E. Lazic, Veronica Bellisario, Marco Giorgio, Pier Giuseppe Pelicci, Enrico Alleva, Hans-Peter Lipp & Francesca Cirulli. Hippocampus, vol. 22, no. 12, pp. 2249–2259, 2012, doi: 10.1002/hipo.22042.

A. O. Mechan, A. Wyss, H. Rieger, and M. H. Mohajeri. Journal of Neuroscience Methods, vol. 180, no. 1, pp. 43–51, May 2009, doi: 10.1016/j.jneumeth.2009.02.018.

L. Hahnefeld, A. Vogel, R. Gurke, G. Geisslinger, M. K. E. Schäfer, and I. Tegeder. Biomedicines, vol. 10, no. 4, Art. no. 4, Apr. 2022, doi: 10.3390/biomedicines10040914. https://www.mdpi.com/2227-9059/10/4/914.

K. E. Simmons, K. L. Healey, Q. Li, S. D. Moore, and R. C. Klein. Alcoholism: Clinical and Experimental Research, vol. 45, no. 11, pp. 2231–2245, 2021, doi: 10.1111/acer.14717.

K. E. Simmons, K. L. Healey, Q. Li, S. D. Moore, and R. C. Klein. Alcohol Clin Exp Res, vol. 45, no. 11, pp. 2231–2245, Nov. 2021, doi: 10.1111/acer.14717.

Simon Lopez-Caperuchipi, Lydia Kürzinger, Sarah Hopp-Krämer, Christiane Albert-Weißenberger, Mila M. Paul, Anna-Leena Sirén and Christian Stetter. Experimental Neurology, vol. 341, p. 113721, Jul. 2021, doi: 10.1016/j.expneurol.2021.113721.

Alexandra Vogel, Annett Wilken-Schmitz, Regina Hummel, Manuel Lang, Robert Gurke, Yannick Schreiber, Michael K. E. Schäfer & Irmgard Tegeder. Sci Rep, vol. 10, no. 1, Art. no. 1, Sep. 2020, doi: 10.1038/s41598-020-71879-x.

S. Muthuraju, S. Taha, S. Pati, M. Rafique, H. Jaafar, and J. M. Abdullah. Int J Biomed Sci, vol. 9, no. 4, pp. 194–204, Dec. 2013.

S. Muthuraju, S. Pati, M. Rafiqul, J. M. Abdullah, and H. Jaafar. Basal Ganglia, vol. 2, no. 3, pp. 143–151, Sep. 2012, doi: 10.1016/j.baga.2012.06.004.

Lvmei Li, Qiang Wang, Xiangping Sun, ZeLong Li a, Shuwei Liu, Xian Zhang, Jinyu Zhou, Rui Zhang, Kunmei Liu, Peng Wang, Jianguo Niu, Yujun Wen and Lianxiang Zhang. International Journal of Biological Macromolecules, vol. 233, p. 123652, Apr. 2023, doi: 10.1016/j.ijbiomac.2023.123652.

Katherine Picard, Kanchan Bisht, Silvia Poggini, Stefano Garofalo, Maria Teresa Golia, Bernadette Basilico, Fatima Abdallah, Naomi Ciano Albanese, Irmgard Amrein, Nathalie Vernoux, Kaushik Sharma, Chin Wai Hui, Julie C. Savage, Cristina Limatola, Davide Ragozzino, Laura Maggi, Igor Branchi and Marie-Ève Tremblay. K. Picard et al., “Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice,” Brain, Behavior, and Immunity, vol. 97, pp. 423–439, Oct. 2021, doi: 10.1016/j.bbi.2021.07.022.

Tsvetan Serchov, Inna Schwarz, Alice Theiss, Lu Sun, Amrei Holz, Mate D. Döbrössy, Martin K. Schwarz, Claus Normann, Knut Biber and Dietrich van Calker. Neuropharmacology, vol. 162, p. 107834, Jan. 2020, doi: 10.1016/j.neuropharm.2019.107834.

S. A. Mohammadi, T. J. Burton, and M. J. Christie. Behavioural Brain Research, vol. 328, pp. 105–114, Jun. 2017, doi: 10.1016/j.bbr.2017.04.005.

M. Jensen et al. International Journal of Neuropsychopharmacology, vol. 19, no. 5, p. pyv123, May 2016, doi: 10.1093/ijnp/pyv123.

N. Kulesskaya, N. N. Karpova, L. Ma, L. Tian, and V. Voikar. Frontiers in Behavioral Neuroscience, vol. 8, 2014.

I. Branchi, S. Santarelli, I. D’Andrea, and E. Alleva. Hormones and Behavior, vol. 63, no. 3, pp. 503–509, Mar. 2013, doi: 10.1016/j.yhbeh.2013.01.003.

I. Branchi, I. D’Andrea, F. Cirulli, H.-P. Lipp, and E. Alleva. Psychoneuroendocrinology, vol. 35, no. 5, pp. 743–751, Jun. 2010, doi: 10.1016/j.psyneuen.2009.10.016.

W. Ujita, A. Kohyama-Koganeya, N. Endo, T. Saito, and H. Oyama. The FEBS Journal, vol. 285, no. 1, pp. 188–196, 2018, doi: 10.1111/febs.14334.

I. Heinla, J. Åhlgren, E. Vasar, and V. Voikar. Physiology & Behavior, vol. 188, pp. 32–41, May 2018, doi: 10.1016/j.physbeh.2018.01.024.

Ekrem Dere, Anja Ronnenberg, Björn Tampe, Sahab Arinrad, Manuela Schmidt, Elisabeth Zeisberg and Hannelore Ehrenreich. Neurobiology of Learning and Memory, vol. 150, pp. 136–150, Apr. 2018, doi: 10.1016/j.nlm.2018.02.023.

J. Y. Holgate, H. Garcia, S. Chatterjee, and S. E. Bartlett. Brain and Behavior, vol. 7, no. 8, p. e00767, 2017, doi: 10.1002/brb3.767.

D. J. Koss et al. Neurobiology of Disease, vol. 91, pp. 105–123, Jul. 2016, doi: 10.1016/j.nbd.2016.03.002.

A. Nowak, T. Werka, and E. Knapska. Behavioural Brain Research, vol. 238, pp. 200–205, Feb. 2013, doi: 10.1016/j.bbr.2012.10.031.

Gao, Y., Han, X., Li, X., Tang, S., Zhang, C., Yang, X., Alhomrani, M., Alamri, A. S., Nabi, G., and Ni, X. Acta Biochimica Polonica, 70(4), Article 4. https://doi.org/10.18388/abp.2020_6720

Li, L., Wang, Q., Sun, X., Li, Z., Liu, S., Zhang, X., Zhou, J., Zhang, R., Liu, K., Wang, P., Niu, J., Wen, Y., and Zhang, L. International Journal of Biological Macromolecules, 233, 123652. https://doi.org/10.1016/j.ijbiomac.2023.123652.

Li, X., Gao, Y., Han, X., Tang, S., Li, N., Liu, X., and Ni, X. Experimental Gerontology, 176, 112168. https://doi.org/10.1016/j.exger.2023.112168

Wu, N., Sun, T., Wu, X., Chen, H., and Zhang, Z. Frontiers in Behavioral Neuroscience, 16. https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1042227

Esmaeili, A., Antonova, A., Sitnikova, E., and Smirnov, K. Behavioural Brain Research, 418, 113627. https://doi.org/10.1016/j.bbr.2021.113627

Pham, H., Yin, T., and D’Adamio, L. PLOS ONE, 17(5), e0263546. https://doi.org/10.1371/journal.pone.0263546

Shishelova, A. Y., Smirnov, K., and Raevskiĭ, V. V. Developmental Psychobiology, 64(7), e22318. https://doi.org/10.1002/dev.22319

Xiao, L., Jiang, S., Wang, Y., Gao, C., Liu, C., Huo, X., Li, W., Guo, B., Wang, C., Sun, Y., Wang, A., Feng, Y., Wang, F., and Sun, T. Journal of Translational Medicine, 20(1), 570. https://doi.org/10.1186/s12967-022-03787-9

Yesiltepe, M., Yin, T., Tambini, M. D., Breuillaud, L., Zehntner, S. P., and D’Adamio, L. Frontiers in Aging Neuroscience, 14.

Cao, G., Wei, X., Li, W., Yin, H., Lang, W., Wei, P., Zhu, Q., and Jin, G. Neuroscience Letters, 763, 136192. https://doi.org/10.1016/j.neulet.2021.136192

Pelsőczi, P., Kelemen, K., Csölle, C., Nagy, G., Lendvai, B., Román, V., and Lévay, G. Frontiers in Behavioral Neuroscience, 13. https://www.frontiersin.org/articles/10.3389/fnbeh.2019.00295

Zheng, Y., Wu, M., Gao, T., Meng, L., Ding, X., Meng, Y., Jiao, Y., Luo, P., He, Z., Sun, T., Zhang, G., Shi, X., and Rong, W. Neural Plasticity, 2020, e8866187. https://doi.org/10.1155/2020/8866187

Oliveros, E., Vázquez, E., Barranco, A., Ramírez, M., Gruart, A., Delgado-García, J. M., Buck, R., Rueda, R., and Martín, M. J. Nutrients, 10(10), Article 10. https://doi.org/10.3390/nu10101519

Wu, N., Wang, F., Jin, Z., Zhang, Z., Wang, L.-K., Zhang, C., and Sun, T. Behavioral and Brain Functions, 13(1), 7. https://doi.org/10.1186/s12993-017-0125-4

Urbach, Y. K., Raber, K. A., Canneva, F., Plank, A.-C., Andreasson, T., Ponten, H., Kullingsjö, J., Nguyen, H. P., Riess, O., and von Hörsten, S. Journal of Neuroscience Methods, 234, 38–53. https://doi.org/10.1016/j.jneumeth.2014.06.017

IntelliCage data have been published in over 500 peer-reviewed articles, including publications in PNAS, Molecular Psychiatry or Nature Communications. The IntelliCage allows a transfer of validated behavioral paradigms into an automated setup, complementing usual behavioral testing procedures.

“The Intellicage system is a great ethological platform providing high-throughput standardized quantification of the home-cage behavior of group-housed mice during circadian cycle. This allows good data comparability and reproducibility, and there is a high flexibility in the protocols to analyze both spontaneous and conditioned responses. In this socially-enriched and ethically-compliant environment, complex behaviors are recorded without major bias due to experimenter intervention and without stress compared to standard tests in which mice stand alone.”

Dr. Cyrille Vaillend
PI (DR1) | NeuroPSI Institute, Paris Saclay University

“…our laboratory has 6 IntelliCages along with add-ons (2 social boxes). I have more than 5 years of experience with this system and can provide only positive feedback regarding IntelliCage. Both hardware and software are reliable, in addition support by TSE is excellent. The system offers a great flexibility in design of various experiments…”

Dr. Vootele Voikar
University of Helsinki

“Following or avoiding other mice in corner visits” … “this is the first method that permits the mapping of the social networks of mice and the effects of those social networks on reward-induced behaviors”

Parkitna et al
PloS One 2014

“We are excited to be using the Intellicage system from TSE to further our understanding of legacies of stress. Being able to perform experiments with minimal experimenter-associated interference has elevated our portfolio of behavioral neuroscience approaches.”

Prof. Brian G. Dias, PhD
Professor of Pediatrics | University of Southern California

“IntelliCage plays a pivotal role in our translational research on Autistic spectrum disorder. We can assess 11 clinically relevant traits in mice within 2 months and screened 8 ASD models so far. This revealed shared (e.g., dominance) and model-specific (e.g., restrictive movement patterns) traits across models, foundational in ongoing drug development, highlighting the immense role IntelliCage plays preceding clinical trials.”

Seico Benner
Senior Researcher | NIES/Hamamatsu University School of Medicine, Japan

Compatible with

Running Wheels

Automated wheels for voluntary or active exercise tests in mice or rats, including workload module for resistance running.

Learn more

PhenoMaster

Metabolic cage system for mouse, rat or larger animals. Suitable for calorimetry, behavioral and physiological studies.

Learn more

Stellar Telemetry

Multichannel implantable telemetry for In-vivo monitoring of physiological parameters.

Learn more

NeuroLux

Wireless battery-free optogenetics system for freely moving animals in any setup.

Learn more

Center of Knowledge

https://www.youtube.com/watch?v=6eJU4l51tUk

https://www.youtube.com/watch?v=6IiERXzP4K8

https://youtu.be/vXnmJ3efW7I?si=UDDLEyzjTGc2xewc

https://youtu.be/5-VV4ISunIw?si=RSN5Wx5vCVVAT59K

https://youtu.be/fz6_nCbIs6Q?si=UvM-FoCdvqg6mcfQ

https://youtu.be/2_XgtLV0Spg?si=Q3It4wtENmPacBIa

http://Biomedical research using IntelliCage

https://youtu.be/Ql1R520Kg5o?si=Qva3DtOR-LOXYRcP

Request Tutorial

Request tutorial

IntelliCage blog posts

Exploring Cognitive Aging: Insights from different Studies in Rodent Models Using the IntelliCage System

Life expectancy has increased greatly over the last decades, but it has been associated with a progressive rise in the incidence of age-related diseases, including…

Learn more

The Power of The Hippocampus: Uncovered Stress-Induced Memory Enhancements

The exciting study titled “Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements” Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements | Journal of Neuroscience (jneurosci.org) explores the intricate link…

Learn more

Elevate Your Research. Start Today.

We provide expert support and high-performance equipment for efficient, reliable preclinical research. Contact us – your success matters.

Request a Quote