PhenoMaster NG

PhenoMaster NG is TSE Systems’ most advanced platform for automated in vivo phenotyping, integrating metabolic, behavioral, and physiological measurements into one synchronized system.
Its Smart Cage Architecture allows full modularity: users can monitor energy expenditure, feeding and drinking patterns, body weight, activity, cognition, and circadian rhythms — all under identical environmental conditions.
Each module communicates in real time with the central data acquisition software, ensuring time-synchronized data streams across all modalities. This combination of precision engineering, data integrity, and animal welfare design sets PhenoMaster NG apart from any other phenotyping platform available today.

PhenoMaster NG consists of a core platform (the metabolic and behavior cages) and multiple plug-and-play modules that can be easily added or removed depending on study requirements.
Each cage is equipped with its own Cage Controller, acting as an independent information hub, digitally linked via Ethernet to the main computer.
This design allows easy expansion, fast upgrades, and independent control of each cage — providing both flexibility and system-level reliability for complex experiments.

Every component of PhenoMaster NG is engineered around animal comfort and data accuracy.
All modules (feeding, drinking, weight, activity, access control, etc.) are attached to the cage lid, maximizing airflow and freeing up to 30% more living space compared to conventional cages.
This transparent design supports normal circadian rhythms, reduces stress, and increases reproducibility.
Combined with plug-and-play connectivity, researchers can reconfigure experimental setups in minutes — without interrupting ongoing studies.

The system is fully modular and scalable, supporting anything from small pilot experiments to large-scale core facility setups.
Users can start with a few cages and later expand up to 64 cages per calorimetry configuration — all running simultaneously with complete synchronization.
Even large installations maintain high data resolution and system stability, making PhenoMaster NG ideal for long-term studies, multi-cohort projects, and pharmacological screening.

PhenoMaster NG minimizes handling and stress throughout the experiment.
Food and water can be refilled directly from the top without opening the cage; weight and activity are recorded automatically and non-invasively.
This allows continuous long-term monitoring without disturbing the animals, leading to more reliable data and fulfilling all key aspects of Replacement, Reduction, and Refinement (3Rs) principles.
Optional climate chamber integration with temperature and humidity control further ensure stable, ethically optimized experimental conditions.

The Climate Board is a high-precision sensor module integrated into each PhenoMaster NG cage lid. It continuously monitors temperature and relative humidity within the cage microenvironment, rather than relying on ambient room or chamber readings.

These parameters are not secondary welfare indicators — they are direct physiological modifiers of metabolic outcomes. Small variations in temperature and humidity, caused by cage position, animal activity, or strain differences, can significantly influence energy expenditure (EE), respiratory exchange ratio (RER), and feeding behavior.

By capturing microclimate data at the individual cage level, the Climate Board enables researchers to correlate subtle environmental fluctuations with metabolic performance and behavioral responses. This ensures data integrity, reproducibility, and animal well-being, setting a new standard for precision in metabolic phenotyping.

All modules are controlled by the PhenoMaster Software Suite, which collects, synchronizes, and stores every signal in a unified time frame.
Raw data are stored in two formats: one editable for flexible analysis and one protected for data integrity and GLP compliance.

The integrated TSE Analytics software extends this by providing advanced visualization, multi-dataset management, and statistical tools — from time-series analysis and regression models to multivariate clustering and PCA.
Data can also be exported to open formats (TXT, CSV) for external analysis.

PhenoMaster NG is designed as an ecosystem — not a single instrument.
It seamlessly integrates with CaloMax HS for indirect calorimetry, ActiMot3 for spontaneous activity, Automatic Access Control for behavioral conditioning, and specialized modules such as Running Wheel, Weightlifting, and Stable Isotope Tracing.
All modules share the same data backbone and synchronized clock, ensuring temporal alignment of metabolic and behavioral events across the entire study.

TSE Systems provides full service coverage with premium warranty on all PhenoMaster NG components, including gas sensors.
Our Annual Maintenance Program offers annual on-site inspection, system calibration, and software updates — plus 25% discounts on spare parts.
The Intelligent Diagnostic System and Remote Support features allow most issues to be resolved within hours, minimizing downtime and maintaining data quality over the system’s lifetime.

Our scientific support team includes PhDs and senior research specialists experienced in metabolic, behavioral, and physiological studies.
Beyond technical troubleshooting, TSE experts provide post-acquisition consultations, helping interpret experimental data and offering guidance based on current literature and best practices.
We are committed to being a long-term scientific partner, not just a system provider — supporting every step from study design to publication.