Startle Response/PPI System

Fully Computerized Platform for Acoustic Startle Reflex and Pre-Pulse Inhibition in Rodents

Table of Contents
Startle Response/PPI System

Sensorimotor Gating

This automated system offers a robust platform for investigating sensorimotor gating in various rodent models.

Sound-Attenuated Environment: The system incorporates a sound-attenuated housing to minimize external acoustic interference, ensuring reliable and accurate measurement of startle responses. This controlled environment allows to isolate and precisely measure the animal’s reflex response to the auditory stimuli.

Integrated Floor Grid and High-Precision Load Cell: The housing features a cage-integrated floor grid upon which the animal stands. This grid connects to a high-precision load cell that precisely detects even subtle changes in the animal’s vertical movement triggered by the startle reflex.

Controlled Auditory Stimulation: A pair of high-quality loudspeakers positioned within the chamber deliver precisely calibrated acoustic stimuli to elicit the startle reflex.

Unique Features and Paradigms

Sound-attenuating housing is used for animal control of the entire environment.

Animal restrainer with shockable floor

Highly customized stimulus base unit and ultrasensitive sensory platform

Startle Response & PPI software package, high multiplexing with up to 8 startle boxes in parallel.

Sensor platform suitable for mice or rats

Ready-to-use system granting an extended lifespan with simplified operation

Benefits Compare to Other Systems.

TSE Startle Box prioritizes experimental standardization by providing soundproofing and environmental control. Our system ensures high-quality research outcomes with its symmetrical and homogeneous auditory environment, offering precise control over stimulus parameters such as amplitude, frequency, and intensity. With parallel flexibility for up to 8 test boxes, researchers can seamlessly integrate optional components like air puffs or shockers for tactile experiments. Furthermore, the system easily interfaces with third-party systems via a simple TTL pulse. Delivered factory-calibrated, our turnkey platform offers a cost-effective solution for mice and rats studies. Additionally, data analysis is made accessible through our user-friendly software, with options for online or offline processing and export in an open format.

Key Components

Sound Attenuating Housing provides the highest level of experimental standardization while assuring animal welfare.

Animal Restrainers are available for rats & mice below the grip, and an easily removable tray facilitates the cleaning process. 

Shockable stainless steel floor grid allowing electric stimulation from 0.1 to 3.1mA- constant or pulsating to evaluate fear-potentiated startle.

The Stimulus Base Unit is equipped with loudspeakers characterized by their high-linearity sound production (4 – 20 kHz, up to 130 dB). 

Additional air-puff valves and LED systems on the flexible arm can be used to deliver aversive or visual stimuli.

Sensor Platform is mounted on an ultra-stable base equipped with a highly sensitive calibrated force sensor.

Trusted by


Ratz-Wirsching, V et al.; (2024). Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease. Frontiers in Neuroscience, 18.

Arinrad, S et al,; (2023). Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity. ELife, 12, e70792.

Montag, D., Pelz, L., & Rathjen, F. G. (2023). Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test. PLOS ONE, 18(1), e0280133.

Pollari, E et al.; (2023). In depth behavioral phenotyping unravels complex motor disturbances in Cstb−/− mouse, a model for progressive myoclonus epilepsy type 1. Frontiers in Behavioral Neuroscience, 17, 1325051.

Managò, Fet al.; (2023). Dopaminergic signalling and behavioural alterations by Comt-Dtnbp1 genetic interaction and their clinical relevance. British Journal of Pharmacology, 180(19), 2514–2531.

McDaniel, K. L et al. .; (2022). Impacts of a perinatal exposure to manganese coupled with maternal stress in rats: Tests of untrained behaviors. Neurotoxicology and Teratology, 91, 107088.

Porceddu, P. F. et al.; (2022). The novel potent GSK3 inhibitor AF3581 reverts fragile X syndrome phenotype. Human Molecular Genetics, 31(6), 839–849.

Lin, X et al.; (2021). Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function, 226(5), 1533–1551.

Ruat, J et al.; (2021). CB1 receptors in corticotropin-releasing factor neurons selectively control the acoustic startle response in male mice. Genes, Brain, and Behavior, 20(8), e12775.

Habermeyer, J et al.: (2020). Comprehensive phenotyping revealed transient startle response reduction and histopathological gadolinium localization to perineuronal nets after gadodiamide administration in rats. Scientific Reports, 10(1), 22385.

Uzuneser, T. C et al.; (2019). Disrupted-in-Schizophrenia 1 (DISC1) Overexpression and Juvenile Immune Activation Cause Sex-Specific Schizophrenia-Related Psychopathology in Rats. Frontiers in Psychiatry, 10, 222.

Vawter, M. P et al. ; (2019). Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association with Memory and Social Impairments and Abnormal Sensorimotor Gating. International Journal of Neuropsychopharmacology, pyz051.