Exercise, Motor Function & Coordination

The TSE Treadmill Systems are computerized electronically-controlled devices designed for forced exercise experiments and testing of fatigue in rats and mice. Animals can exercise over long periods of time to study chronic adaptation to exercise or mechanisms that reverse disease progression.

Treadmills for mice are available for 1 up to 6 animals, rat treadmills for up to 4 animals. Several treadmills can be combined with each other if more measuring places are required.

All treadmills feature an adjustable inclination (software-controlled adjustment on request) for modification of workload. The treadmill belt is driven by a servo-motor controlled by the Treadmill software that allows programming of user-defined speed profiles as a combination of constant speed and acceleration/deceleration phases with adjustable duration (the available speed range depends on the treadmill model). If the animal leaves the belt, this is registered by adjustable infrared sensors. Foot shock or air puff can be added to motivate the animal to stay on the belt.

Time to exhaustion is stored in data files generated for further statistical evaluation.

The Treadmill System is available in a calorimetric configuration (CaloTreadmill) for exercise calorimetry in combination with the TSE PhenoMaster CaloSys module.

Abbasian S, Asghar Ravasi A. The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia. Brain Res 2020; 1729: 146618.

Cui D, Mesaros A, Burdeos G, Voigt I, Giavalisco P, Hinze Y, Purrio M, Neumaier B, Drzezga A, Obata Y, Endepols H, Xu X. Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus. Int J Mol Sci 2020; 21(17): 6297

Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C. Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 2020; 34(11): 15480-91

Raun SH, Henriquez-Olguín C, Karavaeva I, Ali M, Møller LLV, Kot W, Castro-Mejía JL, Nielsen DS, Gerhart-Hines Z, Richter EA, Sylow L. Housing temperature influences exercise training adaptations in mice. Nat Commun 2020; 11(1): 1560

Reynolds JC, Lee C. Mouse Fitness as Determined Through Treadmill Running and Walking. Methods Mol Biol 2020; 2144: 57-65


1, 2, 4, and 6 lane models for mice.
1, 2 or 4 lane models for rats.
Software-programmable speed profiles.
Adjustable inclination: -20 up to +25 degrees.
Individual trial start for each lane ..
Light beam sensors detect when animal leaves the belt..
Optional foot shock or air puff module.


Motor Function.
Motor Performance.
Endurance .

Disease models