The Power of The Hippocampus: Uncovered Stress-Induced Memory Enhancements

The exciting study titled “Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements” Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements | Journal of Neuroscience ( explores the intricate link between stress, memory, and the hippocampus and shows stress-induced memory enhancements. To unravel this paradox, researchers employed a unique combination of behavioral assays, high-resolution fMRI, and cortisol manipulation. The study delves deep into the neural mechanisms at play during stress-induced memory enhancements. Key finding: Stress has a powerful influence on episodic memory, often boosting the encoding of emotionally salient information. Intriguingly, hydrocortisone, a stress-related hormone, emerged as a key player. It not only promoted the encoding of positive, subjectively arousing associative memories, but also led to enhanced functional connectivity between hippocampal subregions.

The mouse model can be very useful in evaluating episodic memory, offering valuable insights for neuroscientific research. In cognitive, emotional and social phenotyping of mice in an observer-independent setting Dere et al. Cognitive, emotional and social phenotyping of mice in an observer-independent setting – PubMed ( introduces a phenotyping battery based on the IntelliCage for comprehensive standardized behavioral assessment. The test battery includes place and reversal learning, sucrose preference, episodic-like memory, behavioral extinction and negative emotional contrast effect, as well as pheromone-based social preference.

Reach out to us to find the best solution for your research field

More news

Exploring Cognitive Aging: Insights from different Studies in Rodent Models Using the IntelliCage System

Life expectancy has increased greatly over the last decades, but it has been associated with a progressive rise in the incidence of age-related diseases, including...

Learn more

Unlocking the Secrets of Gut Microbiota and Host Energy Metabolism: A Novel Approach with PhenoMaster-based Isolator System

The gut microbiota plays a vital role in regulating the host’s energy metabolism. Until recently, studies have shown that mice without microbiota accumulate less fat...

Learn more

Why MotoRater is the best choice for advanced kinematic gait analysis

Rodent (rats and mice) kinematic gait analysis is a fundamental approach to exhibit genomic and neuro-de/re-generative preclinical research. Recent advancements in technologies and analytic tools...

Learn more
scientists used a custom-built Inhalation system for mice from TSE Systems to investigate the combined exposure of mice to aircraft noise and airborne particulate matter (APM)

New study reveals tremendous impact of air pollution and traffic noise on health in mice.

Air pollution is a global environmental crisis that has been linked to an estimated 9 million premature deaths per year, according to The Lancet Commission...

Learn more

Researchers record brain waves of free-swimming octopuses for the first time using the Neurologger

Octopuses are considered one of the most intelligent invertebrates. With over 300 million neurons, octopuses have the most complex invertebrate brain. Their brain is composed...

Learn more

Preclinical Research Trends in 2023

In the coming years, several exciting trends promise to revolutionize how we conduct preclinical animal research. Here are the most significant trends that we can...

Learn more