Exercise, Motor Function & Coordination (+ VO2 max)
4 Different Experiment Modes: training, single, training + single, training + single deactivated
Various Stimulus options: shock, air-puff, or manual pusher
Adjustable Inclination: -20, -10 & up to +25 degrees
Constant and Accelerating Speed
Initial Speed 0.07 – 2.0 m/sec, accelerating time 0-600 sec
Individual Timer per Line
Loading and storage of individual Animal Profiles: up to 200 animals per table
Time and distance traveled: total or during time intervals
Manual delivery of electric stimulus (in some experiment modes)
Tracking of speed when the animal falls off the running surface.
Assessment of animal performance in watts (activated when a value larger than 0 is entered in the Angle of Gradient field)
Recording of the phase number in which the light barrier interruption occurred
Calculation of time from the start of the phase up to the light barrier interruption
A Metabolic Treadmill for small laboratory animals is a fully computerized, electronically controlled system for exercise calorimetry or investigating the effectiveness of drugs or impaired motor coordination of the skeletal muscles. Available for mice and rats, it has one compartment, air-tight cover, and perforated lid for training purposes. The system comes as a stand-alone unit, which is connected to a respirometry system – a module of PhenoMaster.
On-demand, the floor grid can be equipped to apply an electric stimulus.
The system runs according to a user-defined exercise protocol created with the help of user-friendly software. It allows a seamless integration of Stellar telemetry for various physiological data recordings at freely moving animals.
Brynnel, A., Hernandez, Y., Kiss, B., Lindqvist, J., Adler, M., Kolb, J., van der Pijl, R., Gohlke, J., Strom, J., Smith, J., Ottenheijm, C., & Granzier, H. L. (2018). Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy. eLife, 7, e40532.
de Wendt, C., Espelage, L., Eickelschulte, S., Springer, C., Toska, L., Scheel, A., Bedou, A. D., Benninghoff, T., Cames, S., Stermann, T., Chadt, A., & Al-Hasani, H. (2021). Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes, 70(12), 2796–2809
Hingst, J. R., Kjøbsted, R., Birk, J. B., Jørgensen, N. O., Larsen, M. R., Kido, K., Larsen, J. K., Kjeldsen, S. A. S., Fentz, J., Frøsig, C., Holm, S., Fritzen, A. M., Dohlmann, T. L., Larsen, S., Foretz, M., Viollet, B., Schjerling, P., Overby, P., Halling, J. F., … Wojtaszewski, J. F. P. (2020). Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Molecular Metabolism, 40, 101028.
Kim, H. J., Kim, Y. J., Kim, Y. J., Baek, J. H., Kim, H. S., Kim, I. Y., & Seong, J. K. (2023). Microbiota influences host exercise capacity via modulation of skeletal muscle glucose metabolism in mice. Experimental & Molecular Medicine, 55(8), Article 8.
Slater, R. E., Strom, J. G., Methawasin, M., Liss, M., Gotthardt, M., Sweitzer, N., & Granzier, H. L. (2018). Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance. Journal of General Physiology, 151(1), 42–52.